ID F5YU21_MYCSD Unreviewed; 1836 AA.
AC F5YU21;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Phenolpthiocerol synthesis type-I polyketide synthase PpsD {ECO:0000313|EMBL:AEF36212.1};
GN Name=ppsD {ECO:0000313|EMBL:AEF36212.1};
GN OrderedLocusNames=JDM601_2212 {ECO:0000313|EMBL:AEF36212.1};
OS Mycolicibacter sinensis (strain JDM601) (Mycobacterium sinense).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacter.
OX NCBI_TaxID=875328 {ECO:0000313|EMBL:AEF36212.1, ECO:0000313|Proteomes:UP000009224};
RN [1] {ECO:0000313|EMBL:AEF36212.1, ECO:0000313|Proteomes:UP000009224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JDM601 {ECO:0000313|EMBL:AEF36212.1,
RC ECO:0000313|Proteomes:UP000009224};
RX PubMed=21685274; DOI=10.1128/JB.05291-11;
RA Zhang Z.Y., Sun Z.Q., Wang Z.L., Wen Z.L., Sun Q.W., Zhu Z.Q., Song Y.Z.,
RA Zhao J.W., Wang H.H., Zhang S.L., Guo X.K.;
RT "Complete genome sequence of a novel clinical isolate, the nontuberculous
RT Mycobacterium strain JDM601.";
RL J. Bacteriol. 193:4300-4301(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002329; AEF36212.1; -; Genomic_DNA.
DR RefSeq; WP_013829144.1; NC_015576.1.
DR STRING; 875328.JDM601_2212; -.
DR KEGG; mjd:JDM601_2212; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_35_2_11; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000009224; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009224};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 37..459
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1719..1797
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1800..1836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1836 AA; 191307 MW; DF20BF2B38ED017A CRC64;
MTGTSKTSIV NRMSAMGADK RGALTEQFEK ASRIAAAEPI AVVGIGCRFP GEASGPDAYW
DLLAGGRDAI TEIPPDRWDA DEYYDPDPLA PGRMSSKWGG FISDVAGFDA DFFGISPREA
EAMDPQQRLM LEVAWEALEH AGVSPEHLSG IRSAVMMGVY YTEYQGISAS NPNAIDGYSA
TGNAHAVAVG RIAYLLGLRG PAVAMDSACS SSLVTIHMAC QSLRMRESDL ALAGGVSLIL
RPETQIAMAK WGMLSPRGRC HTFDAGADGF VRGEGAGIVV LKRLTDAIRD GDRIVAVVRG
SAVNSDGRSN GLTAPNTIAQ SDAITRALRS ADVAAGSVNL IETHGTGTGL GDPIEFEALA
EVYGRGADKC ALGAVKTNIG HLEAAAGIAG FIKAALAVQR GQIPPNLHFT KWNPAIDPSP
TRLFVPTEMT PWPATEGPRR AAVSSFGLGG TNAHVVLEQG PDPVPAPAPA DPVATLVVSG
KTDQRVAAWA ATLADWLAGP GAEVPLADVA NTLNHHRSRY ARFATVCARD TEQALAGLRA
VAGGYPAPGV VGTRAAQAGK GTVFLYSGQG SQWAGMGRQL LTDEPAFAAA VDELEPDFVA
QVGFSLRDVL ESGEPVVGID RIQPVLVGMQ LALTALWRSH GVEPDAVIGH SMGEVAAAVV
AGALSPADGL KVIATRSRLM ARLSGQGAMA LLELDADSAE KLVAEHSDIT VAVYAAPQQT
VIAGPPDQVD AVIAVVDAQG KLARRVEVDV ASHHPTVDPI LGELAAALAD LKPSAPTIPL
ISTVGQTGGE TAGSFGGPSV ASPSSSLAEP PAFDADYWVH NLRNPVRFSQ AVTAAAAAHA
TFVEVSPHPL LSHAINGNLE AARPAGDTTV TGTLLREQPE ALSFHTNLAT VAPPSAEAPQ
PDGGIGRADL PPRPWQHVRY WAGVTAANRQ SADAHPLLGV HVELPSGHGH VWQADVGTDV
VAWMAHHKVH GQVVMPATGF AEMALAAAGE ALSLPASAVA VNRVEVEQML RVDTRTEVTT
RLLTDGEGAD DLRIEIHSRA PGGAWSRHAV ARVAAAAPES AAAQRPASGG GGTTLSPADF
YTALRRTGLQ HGPAFAALTR IVRKPGGGSE AEIVLPDEAT AHRGYRIHPV MLDAALQCLA
AALPDESLSG SGPGADEATY LPIAVETIRV FGEVGRRARG HAELVSHDDG GILGRVTLTD
DTGTVTAELS GIYLQRVQRR TVPLPLSQKI FDTEWIDAGV PPQAPAAADG SWLVLTEGDE
SRAFAADFAD RFASDSRRVI TADLTSEPAV REAFAQTADD PDRPPAGVLV FADNGSFDPT
AASDRGRELA WSVAATVRTI VSGWHGAAPR LWLVARNGLS VNAGEPGSLE HGDPSICALK
GLVRVLAYEH PDLRTGVVDL DAAADPAATL IAELGLTGTD DVVAWRGETR YAERLKRATL
ESSGAPAVRS DGAYVLTGGL GGIGLVVARW LIDHGAARIV LNSRSQPSDQ QRVVLDELAE
RAQIAVVSGD LAAPGVAESL VAAAQETGLS LRGVVHGAAV IDDQIVVGID HDTLERVWAP
KATGALRLHE ATLGDPGKEL DWWVGFSSTS SLLGAPGQAS YAAASAWLDG LVAWRRAAGL
PAITINWGQW SGVGVAQELK FSALDPIDPA EGMEALEAIL GGDLARVGVA RLRLDRVAAA
FPELQQLGYF ATLAAELDLD SEDDDWPGPE GLKQLEPAEA AKAVVARLGS RIMAIMGYPK
DSAIDPGRPL TELGMDSLMA VRIRNTVRGD FGAEPPVALL LQGASLTDLA ADLTRQLGLA
PQDSAGDGAS EVRSRAQQRA AARQRAASRR KVGDRT
//
