ID F5Z3Y6_MYCSD Unreviewed; 683 AA.
AC F5Z3Y6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Short-chain dehydrogenase AcrA1 {ECO:0000313|EMBL:AEF37214.1};
GN Name=acrA1 {ECO:0000313|EMBL:AEF37214.1};
GN OrderedLocusNames=JDM601_3214 {ECO:0000313|EMBL:AEF37214.1};
OS Mycolicibacter sinensis (strain JDM601) (Mycobacterium sinense).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacter.
OX NCBI_TaxID=875328 {ECO:0000313|EMBL:AEF37214.1, ECO:0000313|Proteomes:UP000009224};
RN [1] {ECO:0000313|EMBL:AEF37214.1, ECO:0000313|Proteomes:UP000009224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JDM601 {ECO:0000313|EMBL:AEF37214.1,
RC ECO:0000313|Proteomes:UP000009224};
RX PubMed=21685274; DOI=10.1128/JB.05291-11;
RA Zhang Z.Y., Sun Z.Q., Wang Z.L., Wen Z.L., Sun Q.W., Zhu Z.Q., Song Y.Z.,
RA Zhao J.W., Wang H.H., Zhang S.L., Guo X.K.;
RT "Complete genome sequence of a novel clinical isolate, the nontuberculous
RT Mycobacterium strain JDM601.";
RL J. Bacteriol. 193:4300-4301(2011).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; CP002329; AEF37214.1; -; Genomic_DNA.
DR AlphaFoldDB; F5Z3Y6; -.
DR STRING; 875328.JDM601_3214; -.
DR KEGG; mjd:JDM601_3214; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3320; Bacteria.
DR HOGENOM; CLU_026975_0_0_11; -.
DR Proteomes; UP000009224; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05263; MupV_like_SDR_e; 1.
DR CDD; cd05233; SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR44196; DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B; 1.
DR PANTHER; PTHR44196:SF5; POSSIBLE MULTI-FUNCTIONAL ENZYME WITH ACYL-COA-REDUCTASE ACTIVITY ACRA1; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR PRINTS; PR00081; GDHRDH.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000009224}.
FT DOMAIN 14..242
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
FT REGION 639..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 73690 MW; 166249002943577F CRC64;
MAVTGHHDRM RYVVTGGTGF IGRRAVSRLL TTKPDAQVWV LVRRESLGRF EALASQPGQA
WGERVKPLVG DLTAENLGLT DTVIDELGSI DHVLHCAAIY DITAGAAEQQ AANVEGTRAV
IGLAKRLDAT LAHVSSIAVA GDYAGEFTEA DFDIGQALPT PYHQTKFEAE ALVRSTPGLR
YRIYRPAVVV GDSRTGEMDK IDGPYYFFPL LARLAALPRL TPMAVPDTGR TNVVPVDYVV
DALVELMHAD GYDGRTFHLT APKSIGLPDI YRAVAAEAGL PPLRAKLPGA VAAPVLNVGG
RARVWRNMVA TQLGLPAEVL DLVNLRPTFI ADATRDALRG TGIEVPRFAE YAPRLWRYWA
QQLDPDRARR GDPAGPLVGR HVVITGASSG IGRASAIAVA ERGGVVFALA RSGEALDELV
AEIRAAGGQA HAFSCDVTDS ASVEHTVKDI LGRFDHVDYL VNNAGRSIRR SVASSTDRLH
DYERTMAVNY FGAVRMVLAL LPHWRERRFG HVVNVSSEGV LAHSPRYSAY VPTKAALDAF
ADVVSTETLS DHITFTTIHM PLVATPMIAP SRKLLPVGAI SAEHAAAMVV RGLIEKPDRI
DTPLGTLAEA GNYVLPGLAR RVLHQVYLGY PDSAAARGVA PATAAQPPRQ SSRRPKRPAR
AITRVRVPRP VKRAVRLVPG VYW
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