ID F5Z621_ALTNA Unreviewed; 1023 AA.
AC F5Z621;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Error-prone DNA polymerase {ECO:0000256|ARBA:ARBA00017273, ECO:0000256|HAMAP-Rule:MF_01902};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|HAMAP-Rule:MF_01902};
GN Name=dnaE2 {ECO:0000256|HAMAP-Rule:MF_01902};
GN OrderedLocusNames=ambt_18805 {ECO:0000313|EMBL:AEF05254.1};
OS Alteromonas naphthalenivorans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Alteromonas/Salinimonas group; Alteromonas.
OX NCBI_TaxID=715451 {ECO:0000313|EMBL:AEF05254.1, ECO:0000313|Proteomes:UP000000683};
RN [1] {ECO:0000313|EMBL:AEF05254.1, ECO:0000313|Proteomes:UP000000683}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 17741 / KACC 18427 / KCTC 11700BP / SN2
RC {ECO:0000313|Proteomes:UP000000683};
RX PubMed=21705606; DOI=10.1128/JB.05252-11;
RA Jin H.M., Jeong H., Moon E.J., Math R.K., Lee K., Kim H.J., Jeon C.O.,
RA Oh T.K., Kim J.F.;
RT "Complete genome sequence of the polycyclic aromatic hydrocarbon-degrading
RT bacterium Alteromonas sp. strain SN2.";
RL J. Bacteriol. 193:4292-4293(2011).
CC -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC translesion synthesis (TLS). It is not the major replicative DNA
CC polymerase. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632, ECO:0000256|HAMAP-
CC Rule:MF_01902};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC subfamily. {ECO:0000256|ARBA:ARBA00007391, ECO:0000256|HAMAP-
CC Rule:MF_01902}.
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DR EMBL; CP002339; AEF05254.1; -; Genomic_DNA.
DR RefSeq; WP_013786166.1; NC_015554.1.
DR AlphaFoldDB; F5Z621; -.
DR KEGG; alt:ambt_18805; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_4_0_6; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000000683; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07434; PHP_PolIIIA_DnaE2; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR HAMAP; MF_01902; DNApol_error_prone; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR023073; DnaE2.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01902};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|HAMAP-Rule:MF_01902};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_01902}.
FT DOMAIN 3..72
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1023 AA; 115954 MW; 1770D941774588AD CRC64;
MYSELFCQSH YSFLTGASSP AQLVTTASFL GYEALAITDE CSVAGVVRAY AEIKQQKLPI
KLIVGSYFRF DDALSFVLLC PNKAAYTELC RIITNARRRS QKGEYQLAEW DLRTIRHCIF
IWLPNTQEEK DNYWATWLTS QPNIKTYIGA QRLLDGYDHH RFATYTQLQE KFEFPVLACT
GVLMHHVDNL PLQHVLHATQ AHTQVSKLGR AALSNAERSL RTVSKLKKLF PEKWIANAID
VARGCLFSLA ELRYQYPSEL IPKGASPTTY LRERVEAGIK VRFPDGLSDV LRALIEKELS
LIREQEYEYF FLTIYDIVQF AKSRKILYQG RGSAANSIVC YCLEITAVDP RQINVLFERF
ISKERNEPPD IDVDFEHQRR EEIIQYIYEK YGRERTAIAS TVICYRFKSA FKDVGKALGF
SESQLSFVMK QINRRDSVIP WQSQLANLGL DPANERVKLL ISITEQLLGT PRHLSQHVGG
FVISSGPLYE LVPVENAAMQ ERTIIQWDKD DIETLGLLKV DVLALGMLSA IRRTFDLLNK
QFPINIDIPF ITKLGDDQQV YDMICQADTV GVFQIESRAQ MSMLPRLKPR RYYDLVVQIA
IVRPGPIQGD MVHPYLLRRH GKEAITYPSE EVKEVLSRTM GVPIFQEQVI KLAMVAAGFS
GGEADQLRRA MASWKKDGRI FEFKEKLIKG MVARGYDTSF SNNLFEQIKG FAGYGFPESH
SASFAVLAYV SCWLKYYFPV EFYVALLNSW PMGFYTPSQL VLDAKRHHVT VQAPCVNASN
YEHLIVECKG DKQIQLGLTL VKGLSEKSAN LIVSCRPSTG YKNIEGVRTL AIRSDELEAL
ASADAFRSIA GNRYQTRWRL MDKQADLPLF EHTNNEDTFN TAPSVAETLI EDYASIGLSV
NDHPVALLHR ERELGFITPA KALLQKPHKS IVKILGCVTG RQAPGSAAGV TFLTLEDHTG
NINVVVWQAT SRAQHKTFLK AKLMQIDGII ERSKEGVIHI IAGKLIDRTS WLEDISMPSR
DFH
//
