ID F5Z699_ALTNA Unreviewed; 394 AA.
AC F5Z699;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=hydroxymethylglutaryl-CoA reductase (NADPH) {ECO:0000256|ARBA:ARBA00012999};
DE EC=1.1.1.34 {ECO:0000256|ARBA:ARBA00012999};
GN OrderedLocusNames=ambt_19605 {ECO:0000313|EMBL:AEF05412.1};
OS Alteromonas naphthalenivorans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Alteromonas/Salinimonas group; Alteromonas.
OX NCBI_TaxID=715451 {ECO:0000313|EMBL:AEF05412.1, ECO:0000313|Proteomes:UP000000683};
RN [1] {ECO:0000313|EMBL:AEF05412.1, ECO:0000313|Proteomes:UP000000683}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 17741 / KACC 18427 / KCTC 11700BP / SN2
RC {ECO:0000313|Proteomes:UP000000683};
RX PubMed=21705606; DOI=10.1128/JB.05252-11;
RA Jin H.M., Jeong H., Moon E.J., Math R.K., Lee K., Kim H.J., Jeon C.O.,
RA Oh T.K., Kim J.F.;
RT "Complete genome sequence of the polycyclic aromatic hydrocarbon-degrading
RT bacterium Alteromonas sp. strain SN2.";
RL J. Bacteriol. 193:4292-4293(2011).
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
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DR EMBL; CP002339; AEF05412.1; -; Genomic_DNA.
DR RefSeq; WP_013786323.1; NC_015554.1.
DR AlphaFoldDB; F5Z699; -.
DR KEGG; alt:ambt_19605; -.
DR eggNOG; COG1257; Bacteria.
DR HOGENOM; CLU_001734_2_2_6; -.
DR OrthoDB; 9794902at2; -.
DR Proteomes; UP000000683; Chromosome.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00643; HMG-CoA_reductase_classI; 1.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR004554; HMG_CoA_Rdtase_eu_arc.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ SEQUENCE 394 AA; 42513 MW; 230176126ECBA8AF CRC64;
MAKIPRSKFY DQSSNDYTAE MAATRREFVK DKTGAEMNHV GTFSIKPDTL PGNIEHFTGV
AQVPIGLAGP LVIKGVDAQG EFYVPMATTE GTLVASYNRG MRLTAESGGV KTTVIDDAMQ
RAPVFVFEDA RAALAFGKWV TDNFELIKAK AEETTSVGKL RDIEQYAVSK MRWLRFNFTC
GDAAGQNMVS KATRHACQWM QAQHIAGLEH FALSGNLDTD KKHSFVNSLH TRGKRVVAET
TIPADLMKSL MHCSPDALFK QRQLSNMGAF VAGSVSNGAH FANGITALFI ACGQDVANVA
ESSAGYTYSE ITPNGDYYFS ITIPSLVVAS YGGGTGLATQ RECLETLGCY GNGRVNKLAE
IIAATVLCGE LSLGAAVVAD EWVSSHDEYG RNRP
//
