UniProt: F6AHD3

Database: UniProt
Entry: F6AHD3_PSEF1

LinkDB:  F6AHD3_PSEF1 
Original site:  F6AHD3_PSEF1

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (12)   
   InterPro (8)   
   Pfam (3)   
   SMART (1)   
All databases (19)   

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ID   F6AHD3_PSEF1            Unreviewed;       436 AA.
AC   F6AHD3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=GDP-mannose 6-dehydrogenase {ECO:0000256|ARBA:ARBA00020994, ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.132 {ECO:0000256|ARBA:ARBA00012932, ECO:0000256|PIRNR:PIRNR000124};
GN   OrderedLocusNames=Psefu_3880 {ECO:0000313|EMBL:AEF23836.1};
OS   Pseudomonas fulva (strain 12-X).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=743720 {ECO:0000313|EMBL:AEF23836.1, ECO:0000313|Proteomes:UP000000686};
RN   [1] {ECO:0000313|EMBL:AEF23836.1, ECO:0000313|Proteomes:UP000000686}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12-X {ECO:0000313|Proteomes:UP000000686};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Pagani I., Davenport K., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Lcollab F.I.,
RA   Woyke T.;
RT   "Complete sequence of Pseudomonas fulva 12-X.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate
CC         + 3 H(+) + 2 NADH; Xref=Rhea:RHEA:21728, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57527, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:84886; EC=1.1.1.132;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- PATHWAY: Glycan biosynthesis; alginate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005182, ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00006601, ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; CP002727; AEF23836.1; -; Genomic_DNA.
DR   RefSeq; WP_013792959.1; NC_015556.1.
DR   AlphaFoldDB; F6AHD3; -.
DR   STRING; 743720.Psefu_3880; -.
DR   KEGG; pfv:Psefu_3880; -.
DR   eggNOG; COG1004; Bacteria.
DR   HOGENOM; CLU_023810_1_1_6; -.
DR   OrthoDB; 9803238at2; -.
DR   UniPathway; UPA00286; -.
DR   Proteomes; UP000000686; Chromosome.
DR   GO; GO:0047919; F:GDP-mannose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0042121; P:alginic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR028358; GDPman_DH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   NCBIfam; TIGR03026; NDP-sugDHase; 1.
DR   PANTHER; PTHR43750:SF1; GDP-MANNOSE 6-DEHYDROGENASE; 1.
DR   PANTHER; PTHR43750; UDP-GLUCOSE 6-DEHYDROGENASE TUAD; 1.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500135; GDPman_DH; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF52413; UDP-glucose/GDP-mannose dehydrogenase C-terminal domain; 1.
PE   3: Inferred from homology;
KW   Alginate biosynthesis {ECO:0000256|ARBA:ARBA00022841,
KW   ECO:0000256|PIRNR:PIRNR000124};
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|PIRNR:PIRNR000124};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000686}.
FT   DOMAIN          317..425
FT                   /note="UDP-glucose/GDP-mannose dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00984"
FT   ACT_SITE        268
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-1"
FT   BINDING         10
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         11
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         30
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         35
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         86
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         124
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         161
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         210
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         214
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         217
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         225
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         256
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         257
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         259
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         262
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         265
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         271
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         324
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         331
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
SQ   SEQUENCE   436 AA;  47359 MW;  5ADB01CD6562FFC2 CRC64;
     MRISIFGLGY VGAVCAGCLS ARGHQVIGVD VSQDKIDMIN QGKSPIVEPG LAALLDQGVG
     NGLLRGTTNV SEAVADSELS FIAVGTPSKR NGDLDLAYME SVCMQIGVAL RDKADRHTVV
     IRSTVLPGTV KNVVIPLLET ASGKKAGVDF GVATNPEFLR ESTAIKDYDF PAMTVIGELD
     EQSGELLQAL YSELDAPIIR KSIEVAEMIK YTCNVWHATK VSFANEIGNI AKACGVDGRE
     VMDVVCQDHK LNLSRYYLRP GFAFGGSCLP KDVRALTYRA GQMDVEHPLL AAIMPSNRVQ
     VKRAYDMISH HGKRKVGLLG LSFKAGTDDL RESPLVELAE MLIGKGYDLR IFDSNVEYAR
     VFGANKEYIE SKIPHVSSLL CQELDEVVGE SDVLIIGNGD KRFAEVMSNA GDDKQFIDLF
     GFMTHTSNST KEGICW
//

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