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Database: UniProt
Entry: F6B4T3_DESCC
LinkDB: F6B4T3_DESCC
Original site: F6B4T3_DESCC 
ID   F6B4T3_DESCC            Unreviewed;       929 AA.
AC   F6B4T3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   24-JAN-2024, entry version 67.
DE   RecName: Full=3'-5' exonuclease DinG {ECO:0000256|HAMAP-Rule:MF_02206, ECO:0000256|RuleBase:RU364106};
DE            EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_02206, ECO:0000256|RuleBase:RU364106};
GN   Name=dinG {ECO:0000256|HAMAP-Rule:MF_02206,
GN   ECO:0000256|RuleBase:RU364106};
GN   OrderedLocusNames=Desca_1336 {ECO:0000313|EMBL:AEF94195.1};
OS   Desulfotomaculum nigrificans (strain DSM 14880 / VKM B-2319 / CO-1-SRB)
OS   (Desulfotomaculum carboxydivorans).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfotomaculaceae;
OC   Desulfotomaculum.
OX   NCBI_TaxID=868595 {ECO:0000313|EMBL:AEF94195.1, ECO:0000313|Proteomes:UP000009226};
RN   [1] {ECO:0000313|EMBL:AEF94195.1, ECO:0000313|Proteomes:UP000009226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14880 / VKM B-2319 / CO-1-SRB
RC   {ECO:0000313|Proteomes:UP000009226};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Lu M., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Stams A., Plugge C., Muyzer G.,
RA   Kuever J., Parshina S., Ivanova A., Nazina T., Woyke T.;
RT   "Complete sequence of Desulfotomaculum carboxydivorans CO-1-SRB.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AEF94195.1, ECO:0000313|Proteomes:UP000009226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14880 / VKM B-2319 / CO-1-SRB
RC   {ECO:0000313|Proteomes:UP000009226};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Lu M., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Stams A., Plugge C., Muyzer G.,
RA   Kuever J., Parshina S., Ivanova A., Nazina T., Woyke T.;
RT   "Complete sequence of Desulfotomaculum carboxydivorans CO-1-SRB.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: 3'-5' exonuclease. {ECO:0000256|HAMAP-Rule:MF_02206,
CC       ECO:0000256|RuleBase:RU364106}.
CC   -!- SIMILARITY: Belongs to the helicase family. DinG subfamily. Type 2 sub-
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_02206,
CC       ECO:0000256|RuleBase:RU364106}.
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DR   EMBL; CP002736; AEF94195.1; -; Genomic_DNA.
DR   RefSeq; WP_013810124.1; NC_015565.1.
DR   AlphaFoldDB; F6B4T3; -.
DR   STRING; 868595.Desca_1336; -.
DR   KEGG; dca:Desca_1336; -.
DR   eggNOG; COG1199; Bacteria.
DR   eggNOG; COG2176; Bacteria.
DR   HOGENOM; CLU_012117_1_0_9; -.
DR   OMA; VVTNHAM; -.
DR   Proteomes; UP000009226; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd06127; DEDDh; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   HAMAP; MF_02206; DinG_exonucl; 1.
DR   InterPro; IPR006555; ATP-dep_Helicase_C.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR006310; DinG.
DR   InterPro; IPR045028; DinG/Rad3-like.
DR   InterPro; IPR006054; DnaQ.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR   InterPro; IPR006554; Helicase-like_DEXD_c2.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR01407; dinG_rel; 1.
DR   NCBIfam; TIGR00573; dnaq; 1.
DR   PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR   PANTHER; PTHR11472:SF34; REGULATOR OF TELOMERE ELONGATION HELICASE 1; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF06733; DEAD_2; 1.
DR   Pfam; PF13307; Helicase_C_2; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00488; DEXDc2; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00491; HELICc2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_02206}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_02206,
KW   ECO:0000256|RuleBase:RU364106}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_02206};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_02206, ECO:0000256|RuleBase:RU364106};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_02206}; Nucleotidyltransferase {ECO:0000313|EMBL:AEF94195.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009226};
KW   Transferase {ECO:0000313|EMBL:AEF94195.1}.
FT   DOMAIN          244..513
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51193"
FT   DOMAIN          266..507
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          738..913
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          207..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           459..462
FT                   /note="DEAH box"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02206"
FT   BINDING         279..286
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02206"
SQ   SEQUENCE   929 AA;  104390 MW;  4957ECC43400EE68 CRC64;
     MFSFVALDLE TTGLDCWSDD IIEIGMVKVI DGQERDFFQS LVRPGGPLPV KIKQLTGLKD
     DDFQSAPLFQ TIIPKILTFI GDLPLVGHNI KFDRDFLAAA CGHQLPNDLY DTFELARILQ
     PSAPSHRLGE LCKIAGVEVN VEHRALDDAR SSARLMLKLL SNLTDTEPEV VWQLSHLLRE
     AGSAWHPVFQ EISNQLLKKF PDKKLGQRIP GAPPLEPTTG DRQKQDKTAI SLTDCLNILG
     PQGAMESTMP RFQYRPQQCD MMGEVVKAFN EDKILLVEAG TGTGKSLAYL VPAIVWARQN
     DERVLITTHT INLQEQLWHK DLPLLANLPD FEFKAALMKG RSNYLCLRRW FALMAEPNHQ
     PEEAHFLARL LVWLHQTITG DKSELFIPYQ ESEYWYRVCS ESDGCLGSRC RFFAEKCFFA
     AARRAAEQAD VVIVNHSLLL SDVNTDNMVL PSYGPLIIDE AHHLENTATE HLGYTSGRSE
     VSRWLTATGR QLQKLEQLVV SVDPEGWQKL LKQSIAAKQT CMDSVTVLFE MLHRWAGQSA
     VNSDFGRYNL RFDRPENPDG VCSLPLAIDT ELDNLLVNIR TFNQLLIKLS ARLEEVITLT
     EDAAGVIKDM ASAISLGQEL ANKLEFIGRS QGDGYVYWLE GSSETDILLR AAPIDVGPLL
     QEKLFSAKRP VVLTSATLSV NGSFDYFIKS IGLDLLPKDS INEKQLDSPF NYSEQVLLCA
     ARDIPQPGDL GDKAYHDVIS SIIYRLSLAA GGRTLVLFTS HRSLREVYHR LKEDFEEQDI
     CLLGHELDGS RGRLVEQFKE GHRTVLFGAA SFWEGVDIPG ETLSCVIIVK LPFSPPNQPV
     VEARLQRIAR QGGNGFHDYQ IPQAVIKFKQ GFGRLIRDPE DKGAVVILDS RLVEKRYGVK
     FFNSLPVTEH FRGSWQQILS KVYIWLNPN
//
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