ID F6EP18_HOYSD Unreviewed; 500 AA.
AC F6EP18;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Precorrin-3B C17-methyltransferase {ECO:0000313|EMBL:AEF40484.1};
GN OrderedLocusNames=AS9A_2035 {ECO:0000313|EMBL:AEF40484.1};
OS Hoyosella subflava (strain DSM 45089 / JCM 17490 / NBRC 109087 / DQS3-9A1)
OS (Amycolicicoccus subflavus).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Hoyosellaceae;
OC Hoyosella.
OX NCBI_TaxID=443218 {ECO:0000313|EMBL:AEF40484.1, ECO:0000313|Proteomes:UP000009235};
RN [1] {ECO:0000313|EMBL:AEF40484.1, ECO:0000313|Proteomes:UP000009235}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45089 / DQS3-9A1 {ECO:0000313|Proteomes:UP000009235};
RX PubMed=21725023; DOI=10.1128/JB.05388-11;
RA Cai M., Chen W.M., Nie Y., Chi C.Q., Wang Y.N., Tang Y.Q., Li G.Y.,
RA Wu X.L.;
RT "Complete genome sequence of Amycolicicoccus subflavus DQS3-9A1T, an
RT actinomycete isolated from crude oil-polluted soil.";
RL J. Bacteriol. 193:4538-4539(2011).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; CP002786; AEF40484.1; -; Genomic_DNA.
DR RefSeq; WP_013806833.1; NC_015564.1.
DR AlphaFoldDB; F6EP18; -.
DR STRING; 443218.AS9A_2035; -.
DR KEGG; asd:AS9A_2035; -.
DR eggNOG; COG1010; Bacteria.
DR eggNOG; COG2243; Bacteria.
DR HOGENOM; CLU_029920_1_0_11; -.
DR OrthoDB; 9804789at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000009235; Chromosome.
DR GO; GO:0030788; F:precorrin-2 C20-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11645; Precorrin_2_C20_MT; 1.
DR CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR InterPro; IPR012382; CobI/CbiL.
DR InterPro; IPR006364; CobI/CbiL/CobIJ_dom.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01467; cobI_cbiL; 1.
DR NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF00590; TP_methylase; 2.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 2.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AEF40484.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009235};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AEF40484.1}.
FT DOMAIN 4..216
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 250..456
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 500 AA; 53468 MW; 4D4DA6EF4A25F3DC CRC64;
MTGKLFGIGL GPGDPELVTV KAARIIAEAD VVAYHSARHG HSIARGVAAP YLRDGQVEEK
LVYPLTTETT DHPRGYQGAI DEFYEESAAR LAAHLDAGRN VALLAEGDPL FYSSYMHMHK
RLSGTYQTEI VPGVTSVAAA SAATQTPLVE RDEVLTVVPG TLPVAELADR LANSDAVAIM
KLGRTFGAVR EALEKSGRLE EAVYVERASW SAQRVLPLKD VEPDEVPYFS VALIPSPLNA
AAPHSSRGEV VVVGLGPGDP EWTTQEVRRE LRAVTDLVGY GPYLARVAPN AWQRHHPSDN
RVEEERAAFA LDLARGGARV AVVSSGDPGV FAMATAVLEV ASRAEYADIP VRVVPGLTAA
NAVAARAGAP LGHDYAVISL SDRLKPWDIV EERLTAAAKA DLAIAIYNPA SKSRTWQVQA
MKETLLQYKS PETPVVIGRA VGSPNEDVKL VPLGSLDPAD VDMRCLLIIG SSQTVMAERS
ASPVVYTPRR YPASSLPQNS
//
