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Database: UniProt
Entry: F6ETZ6_SPHCR
LinkDB: F6ETZ6_SPHCR
Original site: F6ETZ6_SPHCR 
ID   F6ETZ6_SPHCR            Unreviewed;       680 AA.
AC   F6ETZ6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-MAY-2019, entry version 47.
DE   SubName: Full=3-hydroxybutyryl-CoA epimerase {ECO:0000313|EMBL:AEG47803.1};
DE            EC=5.1.2.3 {ECO:0000313|EMBL:AEG47803.1};
GN   ORFNames=Sphch_0101 {ECO:0000313|EMBL:AEG47803.1};
OS   Sphingobium chlorophenolicum L-1.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=690566 {ECO:0000313|EMBL:AEG47803.1, ECO:0000313|Proteomes:UP000007150};
RN   [1] {ECO:0000313|EMBL:AEG47803.1, ECO:0000313|Proteomes:UP000007150}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L-1 {ECO:0000313|EMBL:AEG47803.1,
RC   ECO:0000313|Proteomes:UP000007150};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Daligault H., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Turner P., Copley S., Woyke T.;
RT   "Complete sequence of chromosome 1 of Sphingobium chlorophenolicum L-
RT   1.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
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DR   EMBL; CP002798; AEG47803.1; -; Genomic_DNA.
DR   RefSeq; WP_013846076.1; NC_015593.1.
DR   EnsemblBacteria; AEG47803; AEG47803; Sphch_0101.
DR   GeneID; 35851894; -.
DR   KEGG; sch:Sphch_0101; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1250; LUCA.
DR   KO; K07516; -.
DR   OrthoDB; 977512at2; -.
DR   BioCyc; SCHL690566:G1GN4-101-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000007150; Chromosome 1.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008692; F:3-hydroxybutyryl-CoA epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007150};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Isomerase {ECO:0000313|EMBL:AEG47803.1};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007150}.
FT   DOMAIN      287    463       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      468    552       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      587    672       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   680 AA;  72217 MW;  DBF360E9B3FCB8AF CRC64;
     MIDTQLHGDV LEIVMNNPPV NALGIGVRQG LAQAIAGAQT NPAVKAIVIR GGGKLFSGGA
     DITEFGKPFA EPGLPQVVDA IEASAKPVVA AIHGMALGGG LEVALGCHYR IATPETKLGL
     PEVSLGLLPG AGGTQRLPRL IGVEAALEMI VSGSPVPAAK GAELGLVDKL AAQDQLAAEA
     IAFARTVDGP RRTGDLDASA TADVFERFAE NNKRKIGALD APKACIEAVK AATELPLDQG
     QLKERALFTQ LMNGDQSKAL RHVFFAERAA AKVDGLPKDV ARRPIAKVGV IGAGTMGGGI
     SMNFLSAGIP VTIVEMTQEA LDKGTGLIRK NYEATAAKGR LTMAQVEKAM GLLSPTLDFD
     ALKECDLIIE AVYENMDVKK EIFTRLDGIA KPGALLASNT SYLSIDEIAS ATGRPQDVLG
     LHFFSPANVM KLVEVVRGAK TAPDVLATGM DIGRRIGKVP VVSGVCYGFI GNRMLAPRLN
     GAIAMLVEGA TAEQVDRVSV EFGMPMGPLQ MIDLAGVDIG WHRDPNRIES VRDALNAAGR
     WGQKTGAGFY DYDERRRPAP SPAAQAIIDD FRAREGVAPR AISEDEIVTR TLYVMVNEAA
     HILEEGIAQR ASDIDIVWNY GYGWPRHKGG PMFWADLVGL NKIVDALDRY RDRLGPEFTL
     SPLLARCAKE GRPLERDARA
//
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