ID F6FPJ9_ISOV2 Unreviewed; 798 AA.
AC F6FPJ9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=ComEC/Rec2-related protein {ECO:0000313|EMBL:AEG44731.1};
GN OrderedLocusNames=Isova_1994 {ECO:0000313|EMBL:AEG44731.1};
OS Isoptericola variabilis (strain 225).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Promicromonosporaceae; Isoptericola.
OX NCBI_TaxID=743718 {ECO:0000313|Proteomes:UP000009236};
RN [1] {ECO:0000313|EMBL:AEG44731.1, ECO:0000313|Proteomes:UP000009236}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=225 {ECO:0000313|Proteomes:UP000009236};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Zeytun A., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Siebers A., Allgaier M., Thelen M.,
RA Hugenholtz P., Gladden J., Woyke T.;
RT "Complete sequence of Isoptericola variabilis 225.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP002810; AEG44731.1; -; Genomic_DNA.
DR RefSeq; WP_013839122.1; NC_015588.1.
DR AlphaFoldDB; F6FPJ9; -.
DR STRING; 743718.Isova_1994; -.
DR KEGG; iva:Isova_1994; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR HOGENOM; CLU_010363_4_0_11; -.
DR Proteomes; UP000009236; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009236};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 550..727
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 798 AA; 79233 MW; 926769AFB86AEEF6 CRC64;
MTADLRLAPA ALTAWAAAWW LVGSPGLAGR VAGVGAALLV GFGLAAVRWR GPVLAHGFLA
AACVLAVAAG VHVQAADRAP LEALADLGAT ARLEGRVVSE PRPATFGDDL RWVLSVERVT
ARGVTTRTAA AVEVTAPPPA PAFGAAVSVS ARLRPEQPGR DTAARAVADG VATVTAPPGA
ALAATHVLRT ALLDVTADLS PQARGLVPGA AVGDTSRVPP ELTEAMRVTG LTHVTAVSGA
HFAVVVATLT TACAALRAPR AVRVGVLAAA AVGFVLLVRP EPSVLRAAWT CAVALLGVAL
GRPSAGPAAL ATASTVLLVV DPWLARSFGF ALSCAATAGL VLLSGPLAAR LAPWLGRPLA
FALAVPLAAQ AAVGPVLVLL DPSVPTTAVP ANLLATPALV PATVLGLAAT LLAPVAPGPA
HAVAWLASLA TGWIALVAHW FAEVPGAAVP WPGGIGGALL LAAATAGVLA AVLRRPVGDG
WPRTWREAAR RPLRSLRHPR AGGPPGERVT VALAVGAALV VAVVLVLPRA LAPVGGVPED
WELAACDVGQ GDALVVRTGA ASAVVVDVGP PGDAAGRCLA RLGVERVDLL VLSHFHADHV
GGLEAVLARS EVAAALVSPL DLPAAAAERA RAHLAAAGVP VTVAAPGQEG VAGTMAWHVL
GARAAASGRG EEGDGANDAS VVLALRTAAG LDVVTLGDLE RPGQEALLAE LRAAGWAGGV
DVVKMAHHGS ADQSEALAAL LRPRVTVVSV GDGNGYGHPT DAALDLYAGV GSALVRTDEC
GTAVLVARGG GIALACTD
//
