ID F6GUN3_VITVI Unreviewed; 1987 AA.
AC F6GUN3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN OrderedLocusNames=VIT_06s0004g00450 {ECO:0000313|EMBL:CCB43810.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CCB43810.1, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX PubMed=17721507; DOI=10.1038/nature06148;
RG The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR EMBL; FN594951; CCB43810.1; -; Genomic_DNA.
DR RefSeq; XP_010651384.1; XM_010653082.2.
DR STRING; 29760.F6GUN3; -.
DR PaxDb; 29760-VIT_06s0004g00450-t01; -.
DR EnsemblPlants; Vitvi06g00048_t001; Vitvi06g00048_P001; Vitvi06g00048.
DR GeneID; 100263945; -.
DR Gramene; Vitvi06g00048_t001; Vitvi06g00048_P001; Vitvi06g00048.
DR KEGG; vvi:100263945; -.
DR eggNOG; KOG1175; Eukaryota.
DR HOGENOM; CLU_000747_0_0_1; -.
DR InParanoid; F6GUN3; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000009183; Chromosome 6.
DR ExpressionAtlas; F6GUN3; baseline and differential.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 2..338
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1164..1400
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1568..1964
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 380..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1536..1560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1684..1719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1089
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1685..1719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1987 AA; 214193 MW; E937DA299B44B171 CRC64;
MWTNVFKIGG LHHISWFQFL PHESDLNPPN DKSVKVEQKD PATLVVLSTH LQLQREGFLS
TWTNSFVGPW DPSQGLHNPD EKIKLWLFLP GRHSSVAEAA QVAVSRLRVV ASGFWLAPGD
SEEVAAALSQ ALRNCIERAL IGLNYMRFGD VFSKYHPFSQ SEELFRRGQP TIEFIFAATE
EAIFVHVIIS AKHVRALASG DMEMVLKHSS NKYSESLPVI VSPHGMLGRF TGCCPSDLVK
QVYFSKFKTS NGFIGLPYHL SQGSGCQLRG QNCYVEVTLG CPSAGTDKML QSNSNSIRNF
PKYHVADPHA MGKGAQKGLP DHVSERTFIY PAEAVLVPVL QTSFSRSSLK RFWLQNWIGP
SLSGSSFFTH WAGKTDSLDE SWIDSNGTRT QHSYNSSSNS NDSSISSITS SSSDSDVKMT
TGAGDPEADA DSLTCRQSGL SSNDQLENDC HKLGSKRPRT GISESFGQVG TVNNAPMQDA
YRSGYGSVEV NNSAITGVAS EQISHWDWDD DDRGAVMDIQ ALLSEFGDFG DFFENDALPF
GEPPGTAESH ALIFPAPDCE GSSPCTGMMD VSDQMLLSVG FQSFDNFNPS PPVAMEECLT
KNQEVTNNTL SSGPLNYTPA SSIGEFDHLI KAEALLTFAP EYGAVETPTS ESSSSIFRSP
YLPKSRKVES SNSSAKDYVY GATPPSSPCF DGSDEKPGMP VNSKTCPVRH EASSILHSKK
YYTHVEGGKE QHEKRSFTCD NSIASGEGLT PSSFSGFNST NATKPVQRKT TEGTIGMEHL
VLPMKTVLAT EVECIMFQAS MCKIRHTLLS SSSPPSIGLS RLTGSTVLNS LPGEPSTMTE
NISGKYEVKK KESIPVRIAG DFDGGMLDGP LNATVGVWRT VGVAKGAKPT NSPGVEVSSS
LPHNSFNEEG MLSYGQRQPL QELLDGMAII VQQATSFVDE ALDADCGDGP YGWLALQEQW
RRGFSCGPSM VHAGCGGILA SCHSLDIAGM ELVDPLSADV NASSVFTLIQ SDIKNALKSA
FGILDGPLSA TDWCKGRSQS GDVGTTGDGF SAEHGVNEGR DSSSTVTIGE PISPSQSSAG
GSSCIKVSSV TDGARVDDTC RRRPNQEFSS SESEQQLGSR LRPTLFVLPL PAILVGYQDD
WLKTSANSLQ LWEKAPLEPY ALQKPMAYYV ICPDIDPLTS AAADFFQQLG TVYETCKLGT
HTPQSLGNQM EVDSGKLSSS GFVLLDCPQS MKIESSNSSL LGSISDFFLS LSNGWDLTGF
LKSLSKVLKT LKLGSCLATN PKEGISGPCT VIYVVCPFPE PIALLRTVIE TSVAVGSVIL
SSDKERRSIL QSQVGKALSC PAAVDEASMS NILTLSGFSI PKLVIQIVTV DAIFRVTSPA
LNELAILKET AFTVYNKARR ISRGSSSDIQ SSSLSGRSHS AMMQMASPTS GMWKDCVGPR
ITGPSLSREG ELDAGLRSGT WDNSWQTART GGLSCDPNRN GDFLFQDEVR YMFEPLFILA
EPGSLEHGVS ATAFGNLGSE SLKTLSDDGS GGFMQSASSA GSIDTGPGSQ LDGSESDGFG
SGHQKNLPSL HCCYGWTEDW RWLVCIWTDS RGELLDSHIF PFGGISSRQD TKGLQCLFVQ
ILQQGSQILQ ACSSPDTGIV KPRDLVITRI GSFYELECQE WQKAIYSVGG SEVRKWPLQL
RQAAPDGMSG SSNGSSLQQQ EMSMIQERNL PSSPSPLYSP HSKASGYMKG GLGQPAARKQ
LMGGGHSLVD SSRGLLQWVQ SITFVAVSID HSLSLVFQAD SSTPGATQGG GTMGPSGYLE
GFTPIKSLGS TTASYILIPS PSLRFLPPTP LQLPTCLTAE SPPLAHLLHS KGSAIPLSTG
FVISKAVPAM RKEFRSNAKE EWPSVISVSL IDYYGGNNIT QDKVVRGLTK QGGRSISSEA
RDFEIETHLI LETVAAELHA LSWMTVSPAY LERRTALPFH CDMVLRLRRL LHFADKELSR
TPEKSQV
//
