ID F6GVJ4_VITVI Unreviewed; 796 AA.
AC F6GVJ4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN OrderedLocusNames=VIT_01s0137g00290 {ECO:0000313|EMBL:CCB44013.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CCB44013.1, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX PubMed=17721507; DOI=10.1038/nature06148;
RG The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- FUNCTION: May be involved in the transport of sterols.
CC {ECO:0000256|ARBA:ARBA00003361}.
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DR EMBL; FN594954; CCB44013.1; -; Genomic_DNA.
DR RefSeq; XP_002282089.1; XM_002282053.3.
DR AlphaFoldDB; F6GVJ4; -.
DR STRING; 29760.F6GVJ4; -.
DR PaxDb; 29760-VIT_01s0137g00290-t01; -.
DR EnsemblPlants; Vitvi01g00598_t001; Vitvi01g00598_P001; Vitvi01g00598.
DR GeneID; 100257862; -.
DR Gramene; Vitvi01g00598_t001; Vitvi01g00598_P001; Vitvi01g00598.
DR KEGG; vvi:100257862; -.
DR eggNOG; KOG1737; Eukaryota.
DR HOGENOM; CLU_007105_0_1_1; -.
DR InParanoid; F6GVJ4; -.
DR OrthoDB; 960at2759; -.
DR Proteomes; UP000009183; Chromosome 1.
DR ExpressionAtlas; F6GVJ4; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR CDD; cd13294; PH_ORP_plant; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF67; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1D; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15413; PH_11; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 75..208
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 250..298
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 796 AA; 90826 MW; 5DEC585299F4367D CRC64;
MNPLCCIAPV SIDRDRANPG PCQLGLESSV KNVNIGSKQG FSAQVSSINA ESDAVSHDVE
DAFPEARDGK VFGAGGGVAG ILYKWVNYGK GWRSRWFVLE DGVLSYYKIH GPDKILMSPA
REKSLKVIGE DSLRCMKKNS WSNHHRLAGS AKQWKPFGEI HLKVSSIRAS KSDDKRLSIF
TGTKTLHLRC ISREDRSAWI EALQAAKDLF PRVLTSSDFA PSEDIVVSTE KLRLRLVQEG
VGEVVIKDCE SIMLSELSEL QNQFKALQRK HIILLDTLRQ LETEKIELET TVVDETKERE
SYCGQGNRRF SDFYSIMSEG SGSDSDADNE SQDGVDVETD EDDIVFFDTN DFLSSESLRS
ASYRSRETLG NGTLINNRDP FLSDHLHDEM EIRTVEYPYI KRRDSLPEPK EKEKPVGLWS
IIKDNIGKDL SGVCLPVYFN EPLSSLQKCF EDLEYSYLVD RAMEWGKQGN DLMRILNIAA
FAVSGYASTE GRQCKPFNPL LGETYEADYP DKGLRFFSEK VSHHPMIVAC HCEGRGWKFW
ADSNLKGKFW GRSIQLDPVG VLTLQFDDDE TFQWSKVTTS IYNIILGKIY CDHYGTMRIK
GSGNYSCKLK FKEQSIIDRN PHQVHGFVQD NRTGEKVAML VGKWDEAMYY VLGDPTTKPK
GYDPMTEAVL LWEREKFVTK TRYNLTPFAI SLNELTPGLL EKLPPTDSRL RPDQRHLENG
EYELANAEKL RLEHLQRQAR KLQERGWQPR WFRKDKEDGC YRYIGGYWET REKRYWDGIP
NIFGQGSDSP SCLIEE
//
