ID F6GYK2_VITVI Unreviewed; 712 AA.
AC F6GYK2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN OrderedLocusNames=VIT_09s0054g01120 {ECO:0000313|EMBL:CCB45038.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CCB45038.1, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX PubMed=17721507; DOI=10.1038/nature06148;
RG The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR EMBL; FN594972; CCB45038.1; -; Genomic_DNA.
DR AlphaFoldDB; F6GYK2; -.
DR STRING; 29760.F6GYK2; -.
DR PaxDb; 29760-VIT_09s0054g01120-t01; -.
DR eggNOG; KOG0497; Eukaryota.
DR HOGENOM; CLU_009074_2_0_1; -.
DR InParanoid; F6GYK2; -.
DR Proteomes; UP000009183; Chromosome 9.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0031559; F:oxidosqualene cyclase activity; IEA:UniProt.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 3.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11764:SF85; TERPENE CYCLASE_MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 130..332
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 384..701
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 712 AA; 80579 MW; 42305D651D613350 CRC64;
MWRLKVADGG NDPYMYSTNN FVGRQIWEFD ADYGTPEERA EVEAARENFW KNRFPVKPSC
DLLWRMQFAR ENPCVANLPQ IKVQDLKEVT EEVVMTTLRR GLNFYSTIQA HDGHWPGDYG
GPMFLLPGLN EDGGWGLHIE GPSTMFGTVL SYVTLRLLGE GGFGAEGAME KGRKWILDHG
GATSITSWGK MWLSVLGAYE WSGNNPLPPE VWLCPYILPI HPGRMNCPCR MVYLPMSYIY
GKRFVGPITP TIISLRNELY IVPYQEVDWN QARNQCAKED LYYPHPLVQD ILWASLHKVL
EPILGHWPGN KLREKALCTV MQHVHYEDEN TRYICIGPVN KVLNMLCCWI EDPNSEAFKL
HIPRIFDYLW IAEDGMKMQG YNGSQLWDTC FAVQAIISTN LGEEYGLTLR KAHQFIKNSQ
VLEDCPGDLK FWYRHISKGA WPFSTADNGW PTSDCTAEGL KAILLLSKLP LETVGEPLDM
EQLFDAVNVI LSLQNADGGF ATYELTRSYR WVELINPTET FGDVVIDYPC VECTSAAIQA
LISFKKLYPE HRRHEIENCI SKAAKFIEDI QAPDGSWYGS WGVCFTYGGW FGIKGLIAAG
NTYSNCPCIR KACDYLLSKE LASGGWGESY LSCQSKVYTN LPEDKPNNVN TAWAMLALID
AGQAGRDPNP LHRAARILIN SQMKNGDFPQ EEPSIGLGFF GMLNLYCNIN AW
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