ID F6H2U3_VITVI Unreviewed; 758 AA.
AC F6H2U3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Reticulon-like protein {ECO:0000256|RuleBase:RU363132};
GN OrderedLocusNames=VIT_04s0008g02200 {ECO:0000313|EMBL:CCB46628.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CCB46628.1, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX PubMed=17721507; DOI=10.1038/nature06148;
RG The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363132}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU363132}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; FN595231; CCB46628.1; -; Genomic_DNA.
DR AlphaFoldDB; F6H2U3; -.
DR STRING; 29760.F6H2U3; -.
DR PaxDb; 29760-VIT_04s0008g02200-t01; -.
DR eggNOG; KOG1430; Eukaryota.
DR HOGENOM; CLU_007383_6_8_1; -.
DR InParanoid; F6H2U3; -.
DR Proteomes; UP000009183; Chromosome 4.
DR ExpressionAtlas; F6H2U3; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003388; Reticulon.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR Pfam; PF02453; Reticulon; 1.
DR Pfam; PF14223; Retrotran_gag_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU363132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363132};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363132}.
FT TRANSMEM 390..407
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363132"
FT TRANSMEM 468..501
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363132"
FT DOMAIN 357..547
FT /note="Reticulon"
FT /evidence="ECO:0000259|PROSITE:PS50845"
SQ SEQUENCE 758 AA; 84336 MW; A398273B2AA8F164 CRC64;
MLIRSGRFSV RIADLGPSIK LEPSEEKGLL GEALQSGRAE YVSADLRDKA QVLKACQGAE
AVFHMAAPDS SINNHQLHHS VNVQGTKNVI DACIEQKVKR LIYTSSPSVV FDGVHGIFNG
DESLPYPDKH NDSYSATKAE GEALVIKSNG TNGLLTCCIR PSSIFGPGDK LLVPSLVNAA
RAGKSKFIIG DGNNMYDFTY VENVAHAHIC AEQALASEGK IAEQAAGQAY FITNMEPIKF
WEFVSLILEG LGYERPRIKI PALVMMPIAH MVEWTYKMLA PYGMKVPQLT PSRIRLLSCS
RTFSCSKAKD QLSYTPIVSL QEGLRRTIDS YPDLRAEHLP KREGPSKASR YLGSGRVADT
LLWKDKKLAL TTLLVLMAFY HNFIASGYTI VTAVSKLFLV ASIFLFIHGN LPEKILGYTV
EKIPPSNFHF SEERSHRAAL SVASSWNTAV NVLKSLCKGD DWMLFLKVVL SLLILSFLGA
ISLQSLFVTG LLIAFVAFYI YENKEEEIDR LASEALSFSC KLKSDIAKKL PTFKKFSPSR
LSDVKSLDKL DLESWMEWKS SLQLILALMD LELALYEAKP PMPTVNSSPE DRAKYEKWER
SNRLSLMIMK HKISSSIRSL VPGSGTARQY LARLEVMFIR IAKADAAPLL NKLANMKYDG
QGNVRDHIAN MSGLAARVKA GGIDIPECFV VQLVLDSLPP QYERFQASYK VNWGLEELLC
MCGQEEEFVR LENSERKISA IPGLGPNNEK KYSFLFTR
//