ID F6HE13_VITVI Unreviewed; 4262 AA.
AC F6HE13;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
GN OrderedLocusNames=VIT_05s0020g00410 {ECO:0000313|EMBL:CCB50271.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CCB50271.1, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX PubMed=17721507; DOI=10.1038/nature06148;
RG The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; FN595749; CCB50271.1; -; Genomic_DNA.
DR STRING; 29760.F6HE13; -.
DR PaxDb; 29760-VIT_05s0020g00410-t01; -.
DR eggNOG; KOG1809; Eukaryota.
DR HOGENOM; CLU_223839_0_0_1; -.
DR InParanoid; F6HE13; -.
DR Proteomes; UP000009183; Chromosome 5.
DR ExpressionAtlas; F6HE13; baseline and differential.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR CDD; cd00030; C2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR InterPro; IPR009291; Vps62.
DR PANTHER; PTHR45523:SF6; SHR-BD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45523; TETRATRICOPEPTIDE REPEAT (TPR)-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR Pfam; PF06101; Vps62; 2.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2632..2781
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 442..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2212..2237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4205..4262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4239..4262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4262 AA; 476526 MW; 1A88513790558C3F CRC64;
MFEAHVLHLL RRYLGEYVHG LSAEALRISV WKGDVVLRDL KLKAEALNLL KLPVTVKAGF
VGTITLKVPW KSLGKEPVIV LIDRVFVLAH PAPHGRTLKE DDREKLFEAK IQQIEEAESA
TLEGISRSKL GSPPAANSWL GSLIATIIGN LKISISNVHI RYEDSVSNPG HPFSSGVTLA
KLAAVTIDEQ GNETFDTSGA LDKLRKFLQV ERLAMYHDSN SEPWKIEKKW EDLTPKEWVE
IFEDGINEPA TGGGVVSKWA QNRNYLVSPI NGILKYHRLG KQERNDPEIP FEKASLSLND
VSLTITEAQY HDSIKILEIV SRYKTYIEVS HLRPVASVKE SCYLWWRYAA QASLQQKKMC
YRFSWGRIRH FCHLRRRYVQ LYAGFLQQSL SDSSELRKIE KDLDSKVILL WRLLAHAKVE
SVKSKEAAER RRLKKRSWFS FRGSSPSGDV SVTDASEEPQ LTEGRLTKEE WQAINKLLSY
QPDEELNLPS GKDMQNMIQF LVNVSIGQAA ARIISMNQTE IVCGRFEQLD VSTKFKHRSI
HCDVSLKFYG LNAPEGSLAQ SVSSKQKENA LVASFVRSPV GENVDWRLSA TISPCHATVL
VESYDRFLEF VQRSKVVSPI FALETATALQ MKIEKVTRRA QEQFQMVLEE QSRFALDIDL
DAPKIRVPIR TCGSSRCDSH FLLDFGHFTL HTKETESDEQ RQSLYSRFYI SGRDIAAFFT
DCGSDCQNCT LVAPAYNSRP TISPALKDSD DFCSLVDRCG MAVIVDQIKV PHPSYPSTRV
SVQVPNLGIH FSPARYYRLM ELLDILYGTM EKSNKSTVEN YQAGLAPWSL ADLATDARIL
VWRGIGNSVA AWQPCFLVLS NLYLYILESE TSQSYMRCSS MAGKQVTEVP SSNLGGSLFC
IAVSFRGMDF QKALESSSTL VIEFRDEEEK TTWLRGLTQA TYRASAPALV DVLGESSDGV
TEFGDPRASN LKKADLVING ALLETKLLIY GKVRAEYEGH GKLEEILILE ILAGGGKVHV
VCWEGDLTVK MKLHSLKIKD ELQGRLSTSL QYLACSVHEN DHLFASPRNL DPSVKELSTA
QPEEDDIFKD ALQDFMSLPD QESNLQHMVM PKSAWMEDVT DFAEVDSAVA LIHEMDLGKG
KGTSSETFFE AQDSDHSDFV SVTFLTRNPG SPDYDGVDTQ MSICMSKLEF FCNRPTIVAL
IDFGLDLSSR NSGGSSTNAT KVSDDESSLN KDKTEESECV FVKGLLGYGK SRVIFYLNMN
MDSVTVFLNK EDGSQLAMLV QESFLLDLKV QPTSLSIDGT LGNFRLRDMA FEIDHSWGWL
CDIRNPGVES LIKFTFNSYS VEDDDYKGYD YSLCGRLSAV RIVFLYRFVQ EVTAYFMGLA
TPHTEEVIKL VDKVGDLEWL IQKYEIDGAS AIKLDLSLDT PIIIVPRNSM SKDFIQLDLG
QLEIRNEVSW HGNQEKDPSA VHLDILHAEI LGLNMSVGVN GCIGKPMIRE GQGLDVYVRR
SLRDVFRKIP TFSLEVKVGL LHIVMSDKEY SIILDCACMN LCEEPRLPPS FRGSTTVSED
TMRLLVDKVN MNSHIFLSRN VTIVGVEVNY ALLELCNAIH EESPLAHVAL EGLWASYRMT
SLSETDLYVT IPKFSILDTR LDTKPEMRLM LGSSTDASNQ ASTVNRGGFS MTNLESAPGA
EVATSTMFLM DYRLRVSSQS YVIRLQQPRV LVVPDFLLAV GEFFVPALGA ITGREELMDP
KNDPISRNKS IVLSEPVHKQ IEDVVHLSPS RQLVADALGV NEYTYDGCGK TICLSAETDL
KEIYSSRSQS IIIIGRGKRL RFVNVKIENG SLLRRYTYLS NDSSYSILRE DGVEILLLDE
SSYANDEKSL DYMDETSDTS DTSAYTRSDS SKMQSFTFEA QVVSPEFTFY DGTKSYVGDF
THGEKLLRAK MDLSFMYASK ENDTWIRALM KGLTLEAGSG LTVLDPVDIS GGYTSVKDKT
NISLVATDIC IHLSLSVISL VLNLQNQATA ALQFGNANPL APCTNFDRVW VSPKENGPCD
NLTFWRPRAP SNYVVLGDCV TSSPIPPSQA VMAVSNTYQR VRKPLGFKLI GLFSGIQGLE
AREDNYDMDS DCSLWMPVAP PGYLALGCVA HAGVQPPPSH IVYCIRSDLV TSTTYLECIF
NAPSNPQFSS GFSIWRVDNA LGSFYAHPSG ECPPKNNSCD LSQLVQWNSN RHHSSTKMSS
SDMTIDHDYG SQQASNQSAT SSGWEILRSI SRANNCYMST PNFERIWWDK GSDLRRPFSI
WRPITRPGYA ILGDCITEGL EPPALGIIFK ADNPEISAKP VQFTKVAHIV RKGVDEVFFW
YPIAPPGYAS LGCIVSKTYE APQMDSFCCP RMDLVNPANI LEVPISRSSS SKASQCWSIW
KVENQACTFL ARSDAKKPSS RLAYTIGDSV KPKTRENITA EMKLRCLSLT VLDSLCGMMT
PLFDTTITNI KLATHGRLEA MNAVLISSIA ASTFNTQLEA WEPLVEPFDG IFKFETYDTN
AHPPSRLGKR VRIAATSILN VNVSAANLEA FVETVVSWRR QRELEQKATK LNEEAASHHK
HGDGSNFSAL DEDDFQTVII ENKLGCDMYL KKVEQNSDLV ELLHHDGSAS VWIPPPRFSD
RLNVADEFRE ARYYVAIQIL EAKGLPIIDD GNSHKFFCAL RLVVDSQATD QQKLFPQSAR
TKCVKPLVSK TNDLDEGTAK WNELFIFEVP RKGLARLEVE VTNLAAKAGK GEVLGAFSIS
IEHGKIMLKK VASVRMLHQP HDNHNIVSYP LQKRGQLSND EDMCNLGCLL VSTSYFESKK
VVNFQEDTEN ENRVDRDVGF RVGLGPEGTW ESFRSLLPLS VIPKTLEDDF IAVEVVMKNG
KKHAIFRSLA TVVNDSDVKL DISICSMSMP HSRDPSSETR SRNIVVEEVF QNQRYQSISG
WGNKWHGFPT NDPGHWSTRD FSYSSKDFFE PPLPPGWKWA SGWTIDKPQF VDVDGWAYGP
DYHSLKWPPT SLKSGTKSAV DVVRRRRWIR TREQVTEQGT NNMSVFTVIN PGSSSILPWK
SMSKNSDHCL QVRPCVNYSQ PSYSWSQAVS VGSDHAMKQG NKMAVVTFKL NELEKKDMLL
CCRPDTGSKL FWFSVGADAS VLHTELNSPV YDWKISINSP LKLDNRLPCP AEFTIWEKTK
EGNSLEREHG IISSRKSVHI YSADVQRPIY LSLFVQGGWV LEKDPILVLD LSSNEHVASF
WMVHQQSKRR LRVRIERDMG ECSAAPKTIR FFVPYWISND SSLSLAYQVV EIEPVDNADV
DSLLLSRAVR SAKTALKNPM NSMERRHPGG RKNIQVLEVI EDTSPTPSML SPQDYAGRSG
VNLFPSRNEA HLSPRVGISV AIRHSENFSP GISLFELENK GRVDVKAFYS DGSYYKLSAL
MNMTSDRTKV VHFQPHTLFI NRVGCSLCLQ QCYSQSEEWI HTTDPPKTFG WLTSAKVELL
KLRLDGYKWS YPFSIDTEGV MCISLKKDTG SEKANLRVEV RSGTKSSHYE VIFRPNSSSS
PYRIENHSMF LPIRFRQVDG ASDSWRSLPP NAAASFLWED VGRKRLLELL VDGTDLKKSE
KYNIDEIFDH QPIHVSGAPV KALRVTILKE EKMNVIKISD WMPENEPLAI TSERLPPSLL
QFSTSDQHQE SLSTCEFHVI VEIAELGLSI IDHTPEEILY LSVQNLLFSH SSGLGSGISR
FKLRMLGIQV DNQLPLTPMP VLFRPQRVGD ETDYILKFSM TLQSNGSLDL CVYPYIGFHG
PENSAFLINI HEPIIWRLHE MIQQVNLNRL YDSQTTAVSV DPIIQIGVLN ISEVRLRVSM
AMSPSQRPRG VLGFWSSLMT ALGNMENMPI RINQRFHENV CMRQSALISN AISNIQKDLL
SQPLQLLSGV DILGNASSAL GHMSKGVAAL SMDKKFIQNR QRQENKGVED IGDVIREGGG
ALAKGLFRGV TGILTKPLEG AKSSGVEGFV QGVGKGIIGA AAQPVSGVLD LLSKTTEGAN
AVRMKIASAI TSEEQLLRRR LPRVIGGDNL LHPYDEYKAQ GQVILQLAES GSFFSQVDLF
KVRGKFALSD AYEDHFLLPK GKILVVTHRR VILLQQPSNI IGQRKFSPAR DPCSVLWEVL
WDALVTMELI HGKKDHPKAP PSCLILYLQT KSTESKDQAR VIKCSHESHQ ALEVYSSIER
AMGTYGPKQS KATPKKKVTK PYAPTADGTS AEMLPKEGTG QWSPQQMPAS VLPRSTFGSG
TN
//
