ID F6HK37_VITVI Unreviewed; 1085 AA.
AC F6HK37;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
GN OrderedLocusNames=VIT_12s0035g01160 {ECO:0000313|EMBL:CCB55040.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CCB55040.1, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX PubMed=17721507; DOI=10.1038/nature06148;
RG The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR EMBL; FN595990; CCB55040.1; -; Genomic_DNA.
DR RefSeq; XP_002264666.1; XM_002264630.3.
DR AlphaFoldDB; F6HK37; -.
DR STRING; 29760.F6HK37; -.
DR PaxDb; 29760-VIT_12s0035g01160-t01; -.
DR EnsemblPlants; Vitvi12g02058_t001; Vitvi12g02058_P001; Vitvi12g02058.
DR GeneID; 100248927; -.
DR Gramene; Vitvi12g02058_t001; Vitvi12g02058_P001; Vitvi12g02058.
DR KEGG; vvi:100248927; -.
DR eggNOG; KOG0437; Eukaryota.
DR HOGENOM; CLU_004174_1_1_1; -.
DR InParanoid; F6HK37; -.
DR OrthoDB; 5472610at2759; -.
DR Proteomes; UP000009183; Chromosome 12.
DR ExpressionAtlas; F6HK37; baseline and differential.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IBA:GO_Central.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IBA:GO_Central.
DR GO; GO:0009791; P:post-embryonic development; IEA:UniProt.
DR GO; GO:0048608; P:reproductive structure development; IEA:UniProt.
DR CDD; cd07959; Anticodon_Ia_Leu_AEc; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR004493; Leu-tRNA-synth_Ia_arc/euk.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00395; leuS_arch; 1.
DR PANTHER; PTHR45794:SF1; LEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR45794; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 2.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183}.
FT DOMAIN 21..105
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 193..754
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 794..924
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT REGION 114..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1085 AA; 122695 MW; 40A4EACE401F7D41 CRC64;
MEGSKSFARR DRLLEIEVKV RNWWEEKDVF RAEAGEKPPE PGEKFFGNFP YPYMNGFLHL
GHAFSLSKLE FAAAFHRLRG ANVLLPFGFH CTGMPIKASA DKLAWEIQQF GDPPVFPTEV
EEQPGEEPEP EDPNGGAPAL PDKFKGKKSK AASKSSGQMY QWEIMRSFGL SDSEISKFQN
PYNWLSFFPP LAMEDLKAFG LGCDWRRSFI TTDMNPYYDN FIKWQMRKLK AIGKIVKDVR
YTIYSPLDGQ PCADHDRASG EGVQPQEYTL IKMEVVSPYP PKLSSLEGKK VYLAAATLRP
ETMYGQTNAW VLPDGKYGAF EINDDEVFII TQRAALNLAY QNFSKVPEKP TCLVELTGYD
LIGLPLKSPL SFNEIIYSLP MLSILTDKGT GIVTSVPSDA PDDYMALHDL KSKPAFRAKY
GVKDEWIMPF EIIPIIDIPE YGDRSAEKVC NDLKIKSQNE KEKLAEAKRL TYLRGFTEGT
MLVGEFAGRK VQEAKPLIRS KLIEIGQAIV YSEPEKRVMS RSGDECVVAL TDQWYIIYGE
PEWKKLAEDC LSNMNLYSDE TRHGFEHTLS WLNQWACSRS FGLGTRFPWD EEFLVESLSD
STIYMAYYTV AHILQNGDLY GSGTSSVKPE QMTDEVWDFL FSGGPYPTSS DIPSSILNKM
KQEFEYWYPF DLRVSGKDLI QNHLTFCIYN HTAIMSKNHW PRGFRCNGHI MLNSEKMSKS
TGNFRTLRQA IEEFSADATR FSLADAGDGV DDANFVFETA NAAILRLTKE LSWMEEVLEA
EASLRTGALS TYADQVFANE INIAVTLTEQ HYRNCMFREA LKTGFYDLQA ARDEYRFSCG
AGGMNHDLVW RFMDVQTCLI TPICPHYAEY VRREILKKDG FAVHAGWPTA DSPDLTLKAA
NKYLQDSIVL MRKLLQKQIL GSKKANKKGA PVTSLTESNL KGLIYVNEQY DGWKEECLRI
LQSKFDSRNR TFAADKEILE ALQRSSVGQA TNSKQVQKLC MPFLRFKKDE AVALGPQALD
LRLPFGEIEV LRGNLDLIKR QLGLEQVEIL SGTDPDALAK AGNLVSLLNQ NPPSPGNPTA
IFLTI
//
