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Database: UniProt
Entry: F6PG07_ORNAN
LinkDB: F6PG07_ORNAN
Original site: F6PG07_ORNAN 
ID   F6PG07_ORNAN            Unreviewed;       836 AA.
AC   F6PG07;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   31-JUL-2019, entry version 58.
DE   SubName: Full=ADAM metallopeptidase domain 19 {ECO:0000313|Ensembl:ENSOANP00000008055};
GN   Name=ADAM19 {ECO:0000313|Ensembl:ENSOANP00000008055};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000008055, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000008055, ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000008055,
RC   ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000008055}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000008055};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AAPN01049142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPN01049143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPN01049144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPN01049145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPN01049146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9258.ENSOANP00000008055; -.
DR   Ensembl; ENSOANT00000008057; ENSOANP00000008055; ENSOANG00000005077.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   GeneTree; ENSGT00940000159624; -.
DR   InParanoid; F6PG07; -.
DR   OMA; CNRKELD; -.
DR   TreeFam; TF314733; -.
DR   Proteomes; UP000002279; Chromosome X1.
DR   Bgee; ENSOANG00000005077; Expressed in 4 organ(s), highest expression level in heart.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:InterPro.
DR   GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:InterPro.
DR   GO; GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR033596; ADAM19.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   PANTHER; PTHR11905:SF19; PTHR11905:SF19; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00117091};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    620    641       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      126    324       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      332    418       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DOMAIN      567    599       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REGION      670    836       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    675    691       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    699    726       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
FT   DISULFID    390    410       {ECO:0000256|PROSITE-ProRule:PRU00068}.
FT   DISULFID    571    581       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    589    598       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   836 AA;  91487 MW;  57A9CA243B125927 CRC64;
     YLFAPGYTET HYSESGAPQT STLKNRDRCF YHGTVRGMEQ SSVTLSTCQG IRGLIVVSHN
     LSYIMEPLPG DQERHLIYRL EHLKFPQGTC RQVHSTSAAM DWLTHFTSQA KAGHGRVKRE
     DLQSMKYVEL YLVADYAEFQ KNQRSLEATT YKLMEIANHV DKFYRSLNIR IALVGLEVWT
     HGDKCNVSEN PYSTLWSFLS WRRKLLTQKN HDNAQLITGM SFRGTTIGLA PLMAMCSVYQ
     SGGVNMDHSE NAIGVAATMA HEMGHNFGMS HDSTGCCSAS AEEGGCIMAS ATGHPFPKVF
     NRCNRKELDR YLQSGGGMCL LNMPDTRTLY GGQRCGNGYL EDGEECDCGE EEECSNPCCN
     ASNCTLKAGA ECAHGSCCHQ CKLMAPGTLC REQSQQCDLS EYCTGKTPLC PTNFYKMDGT
     PCEGEQAFCY NGMCLTYQQQ CQQLWGPGAR PAPDLCFEKV NAAGDTFGNC GKDMYGRHRK
     CDTSRDAKCG KIQCQSSASK PLESNAVPID TTILLDGRQI QCRGTHVYRG PEEEGDMLDP
     GLVMTGTKCG FNHICFEGQC RNTSFFDTRG CGEKCNGHGV CNNNRNCHCS QGWAPPFCKR
     AGNGGSIDSG PMPPQSSAPM VAGVLVGIVL LLALSVVICY YRCNKLSPLK TPALPSKWRQ
     PFRCPFKVAQ KGGSGHANPT FNLQTPQGKR KMINTPEIPR KPSQPPPRPP PDYKVSGTPP
     PPLPVSIRRD VRSSPGSSPR VEAKDLARRP PPSRPVPPVP NYVVSQDFSR PRPPQKALPA
     SPVPGRKVVP GSVPASALLP STAGRSPGQP RPLTRAVQKP QDLRSHGVGE ATRSKI
//
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