ID F6PH72_CIOIN Unreviewed; 549 AA.
AC F6PH72;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000001418.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000001418.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6PH72; -.
DR STRING; 7719.ENSCINP00000001418; -.
DR Ensembl; ENSCINT00000001418.3; ENSCINP00000001418.3; ENSCING00000000781.3.
DR GeneTree; ENSGT00950000183076; -.
DR HOGENOM; CLU_000972_0_0_1; -.
DR InParanoid; F6PH72; -.
DR OMA; EAYMITL; -.
DR Proteomes; UP000008144; Unplaced.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 1..117
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 317..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 384..418
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 549 AA; 63326 MW; F5FA0C2CB41EFF43 CRC64;
MKHEEVQKRV EESITQLRTV TDAFLTAILG SIEEIPYGLR YIAKCLQNLL KNKFPDTPED
EVLKMVGNLI YYRYMNPAIV APDGFDVIDV SAGSAGPNND QRRNLGSIAK VLQFASTGKT
FAGDMEHLRS INEYLMQAYE RFKKYFAAVC DVPEPEEKYN IDEYSDAVLL VKPVIFISLK
EILDTHKLLL EHEDEVASDA SDPIHEMLEE LGEVPDIASL IGTNMLKSPR KGEPGGVQPT
EEQRTELLKT EISLTLASKV EIKEDDESDI KNLILRTKRM VIDIIRIQVG ENLTEVLNTP
ATDDQEDLHM KNIEKLEQEK KKREGDKEDK ESMLRTRSLL NENKLPLEDM KRRVVRNLKK
LEEHGIVKSE DHYQTIVNMI ARDIRNQRRY RQRRKQELAK LKQNNDRLDQ KSKFFEEQSD
YYNQYIKSCL ASLANKSKKA QKKKKRKVAN IKYTASELHR KKVLLEIEGL ETGQFRNVMF
EIGQTEEDVG KFEVSAKLLG VSMEKVTLVF QDLLQLQYEG VSVMKMFDGR AKINVNLLIF
LLNKKFFGK
//
