ID F6PHG0_MONDO Unreviewed; 1190 AA.
AC F6PHG0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000027597.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000027597.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000027597.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6PHG0; -.
DR Ensembl; ENSMODT00000029136.3; ENSMODP00000027597.3; ENSMODG00000004142.4.
DR eggNOG; ENOG502QRT8; Eukaryota.
DR GeneTree; ENSGT00940000163592; -.
DR HOGENOM; CLU_004152_0_0_1; -.
DR InParanoid; F6PHG0; -.
DR OMA; YSHGRAN; -.
DR TreeFam; TF316401; -.
DR Proteomes; UP000002280; Chromosome X.
DR Bgee; ENSMODG00000004142; Expressed in spermatid and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IBA:GO_Central.
DR CDD; cd00063; FN3; 8.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF14; FIBRONECTIN TYPE III DOMAIN CONTAINING PROTEIN 3C1-RELATED; 1.
DR Pfam; PF00041; fn3; 5.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 6.
DR PROSITE; PS50853; FN3; 8.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1165..1189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 284..383
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 464..558
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 562..656
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 657..753
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 754..847
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 854..943
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 944..1039
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1042..1139
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 125..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..169
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1190 AA; 131320 MW; 9FEA8D387C06A062 CRC64;
MAEQVPTLEP TTVVNDMPLP PHMVNGDSMQ QVILVQVNPG ETFTIRTEDG HIQCIQGPAH
VPMMSLNGSM PPIFVPPGYM SQVVEENGVR KIVILPHSTD YHPAMHPPPH MQHYMHPHPP
PLLAHPMYPP VPGSELHPPQ YMHQHPMPPP PPPPPPPPPP PPPPPLPQLR MYHEYESRSH
GRTHYIPRDE RTGKMQEHLK KRIKDRHAIG HNNNNNKSGV PPSSLSKGQS SYNANAENGY
GKGQYVVEEP AKQKESGKAK DNAPEEAKAA EPEKEIKELQ DLFSTGKPIV SNIQARSAVL
SWSHLVSSPN EEKASRPVSF TFEVALSNCG KSGKFKTIYI GDEVTVSLPD LQPATDYHVR
VSATYSSIEE STSEVISFTT ESCEPDRPAV PKLVNRTKNS LILQWKGKPG TFKECYFGHL
KQYKLTKLAP STKYSFRLAA KNNLGISEFS ETVAFNTTGS VPPAPPPPQL NQAGITTLSL
DWSPPPGAAT EESHFTYTLE MEEEGSGHGF KAKYNGEEPS CTLKNLRRST SYKFRLFAHN
SEGKSNPSEE VEYTTYPDKP GPPSKPYTKG KIRAYNVKVA WDPPKDNGGA EISKYVLEIS
EASNGNTWNV IYDGTLREHV CDHLRPGTSY KLRVFCFGIA GQSQASDILS IHTSAVPPGP
CRSPYLANRA KPREISLHWA PPVVNGGAEI IDYVVDMAES DQAECRRVYQ GPGLRCTVSN
LLPGRTYSFW IKAANKTGFG PYSAKSQIST APGPPDQCGV PLLTCKTATS VAVSWEVPMC
NGAEICDYRL EWGKLEGSMH VIYTGPCLNY EVKGLTPATT YFCRVQAVNM AGIGMFGGTG
IVTTPASVPG AMSLPRLLEG KIPLPLASTC LALQWDEPNC HGSEITGYNI EYGERQIVTV
DRVTSYTLEN LQPDTVYRIR IQAINSLGQS PFSQSIKAKT KPLPPDPPVL ECVCFSYQSL
KLKWGDGPNR ISLSSSVQFN LQMEDKTGRF VTLLNGPCHT YKVQRLSECT TYNFKIQAYN
EAGEGPFSDI YTFTTTKSPP AALKAPKICQ LEENLCEVTW EPLPPMKGDS IIYILQLVSG
RGADQVYKGP DTSFCFTNFQ TNCEYRFRVC AGRQYQQNGG LQELLGAYSP STVFSSQKKD
IDPPQDDDLI EENKSKKRCL TDDQFAFILV VAFAIIAVLC AVAIQYFLIK
//
