ID F6PJE5_HORSE Unreviewed; 239 AA.
AC F6PJE5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Ribosome assembly factor mrt4 {ECO:0000256|RuleBase:RU364039};
GN Name=MRTO4 {ECO:0000313|Ensembl:ENSECAP00000010495.2,
GN ECO:0000313|VGNC:VGNC:20375};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010495.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010495.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010495.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010495.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010495.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ribosome assembly machinery. Nuclear paralog
CC of the ribosomal protein P0, it binds pre-60S subunits at an early
CC stage of assembly in the nucleolus, and is replaced by P0 in
CC cytoplasmic pre-60S subunits and mature 80S ribosomes.
CC {ECO:0000256|ARBA:ARBA00004046, ECO:0000256|RuleBase:RU364039}.
CC -!- SUBUNIT: Associates with the pre-60S ribosomal particle.
CC {ECO:0000256|RuleBase:RU364039}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364039}.
CC Nucleus, nucleolus {ECO:0000256|RuleBase:RU364039}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC {ECO:0000256|ARBA:ARBA00008889, ECO:0000256|RuleBase:RU364039}.
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DR AlphaFoldDB; F6PJE5; -.
DR SMR; F6PJE5; -.
DR STRING; 9796.ENSECAP00000010495; -.
DR PaxDb; 9796-ENSECAP00000010495; -.
DR Ensembl; ENSECAT00000013242.4; ENSECAP00000010495.2; ENSECAG00000012598.4.
DR VGNC; VGNC:20375; MRTO4.
DR GeneTree; ENSGT00390000006238; -.
DR HOGENOM; CLU_071690_3_0_1; -.
DR InParanoid; F6PJE5; -.
DR OMA; LEWAENY; -.
DR OrthoDB; 23333at2759; -.
DR TreeFam; TF300111; -.
DR Proteomes; UP000002281; Chromosome 2.
DR Bgee; ENSECAG00000012598; Expressed in trophectoderm and 23 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR CDD; cd05796; Ribosomal_P0_like; 1.
DR Gene3D; 3.30.70.1730; -; 1.
DR Gene3D; 3.90.105.20; -; 1.
DR InterPro; IPR033867; Mrt4.
DR InterPro; IPR001790; Ribosomal_uL10.
DR InterPro; IPR040637; Ribosomal_uL10-like_insert.
DR InterPro; IPR043164; Ribosomal_uL10-like_insert_sf.
DR InterPro; IPR043141; Ribosomal_uL10-like_sf.
DR PANTHER; PTHR45841:SF1; MRNA TURNOVER PROTEIN 4 HOMOLOG; 1.
DR PANTHER; PTHR45841; MRNA TURNOVER PROTEIN 4 MRTO4; 1.
DR Pfam; PF00466; Ribosomal_L10; 1.
DR Pfam; PF17777; RL10P_insert; 1.
DR SUPFAM; SSF160369; Ribosomal protein L10-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU364039};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364039};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Ribosome biogenesis {ECO:0000256|RuleBase:RU364039}.
FT DOMAIN 125..194
FT /note="Large ribosomal subunit protein uL10-like insertion"
FT /evidence="ECO:0000259|Pfam:PF17777"
FT REGION 215..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..239
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 27540 MW; 0119E7D250B8E5B7 CRC64;
MPKSKRDKKV SLTKTAKKGL ELKQNLIEEL RKCVDTYKYL FIFSVANMRN SKLKDIRNAW
KHSRMFFGKN KVMMVALGRS PSDEYKDNLH QVSKKLRGEV GLLFTNRTKE EVNEWFTKYT
EMDYARAGNK ATFTVSLEPG PLEQFPHSME PQLRQLGLPT ALQRGVVTLL SDHEVCKEGD
VLTPEQARVL KLFGYEMAEF KVTIKYMWDA QSGRLQQMGD ELPESASESE EESEEEDDG
//
