ID F6PKF0_HORSE Unreviewed; 908 AA.
AC F6PKF0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=MutS homolog 4 {ECO:0000313|Ensembl:ENSECAP00000015050.4};
GN Name=MSH4 {ECO:0000313|Ensembl:ENSECAP00000015050.4,
GN ECO:0000313|VGNC:VGNC:20387};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015050.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000015050.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015050.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000015050.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015050.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6PKF0; -.
DR STRING; 9796.ENSECAP00000015050; -.
DR PaxDb; 9796-ENSECAP00000015050; -.
DR Ensembl; ENSECAT00000018447.4; ENSECAP00000015050.4; ENSECAG00000017096.4.
DR CTD; 4438; -.
DR VGNC; VGNC:20387; MSH4.
DR GeneTree; ENSGT00550000074897; -.
DR HOGENOM; CLU_002472_7_2_1; -.
DR InParanoid; F6PKF0; -.
DR OMA; KMTMLYK; -.
DR OrthoDB; 168255at2759; -.
DR TreeFam; TF300572; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000017096; Expressed in testis.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR CDD; cd03243; ABC_MutS_homologs; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 726..742
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 101361 MW; 90A85D0991327A74 CRC64;
MLRPEMSSSS PSVPVVSSSA VARSQGPRYS FGFRETSGSR SSALAFSAPT PPGTSGAAGD
RSSSSSLPRL PPSAGPARGS FFGNKRSYAE NTFASNFTFG TSSSSVRDSN YPQMLKTPLS
VGNPQGSGYK SWTPQVGYSA TSSSAVSAHS SSVIVAVVEG RGLARGEIGM ASIDLKSPQI
ILSQFADNTT YAKVITKLKI LSPLEIIMSN TACVVGNSTK LFTLITENFK NVNFTTIQRK
YFNETKGLEY IEQLCIAEFS TVLMEVQSKY YCLAAVAALL KYVEFIQNSV YAPKSLKICF
QGSEQTAMID SSSAQNLELL INNQDCRNNH TLFGVLNYTK TPGGSRRLRS NILEPLVDIE
TINMRLDCVQ ELLHDEELFF GLQSVISRFL DTEQLLSVLI QIPKQDTIAL KNCDTPLLRA
YYGSLEDKRF GIILEKIKTV INDDARYMKG CLNMRTQKCY AVRSNINEFL DIARRTYTEI
VDDIAGMISQ LAEKYSLPLR TSFSSARGFF IQMTTDCTAL PDDQLPSEFI KISKVKNSYS
FTSADLIKMN ERCQESLREI YHMTYMIVCK LLSEIYEHIH CLYKLSDTVS MLDMLLSFAH
ACTLSDYVRP EFTDTLAIKQ GWHPILEKIS VEKPVANNTY ITEGSNFLII TGPNMSGKST
YLKQIALCQI MAQIGSYVPA EYSSFRIAEQ IFTRISTDDD IETNSSTFMK EMKEIAYILH
NANDKSLILI DELGRGTNTE EGIGICYAVC EHLLSLKAFT LFATHFLELC HIDVLYPNVE
NMHFEVQHVK NTSRNKEAIL YTYKLSKGLT EEKNYGLKAA EVSSLPPSIV LDAKEITTQI
TRQILQNQKS TPEMERQRAV YHLATRLVQT ARNSQLDADS LRTYLSNLKK KYEADFPKSE
QVSGETEQ
//
