ID F6PLF2_CANLF Unreviewed; 192 AA.
AC F6PLF2;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Amelogenin X isoform {ECO:0000313|EMBL:AKD44024.1};
GN Name=AMELX {ECO:0000313|EMBL:AKD44024.1,
GN ECO:0000313|Ensembl:ENSCAFP00845037153.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845037153.1, ECO:0000313|Proteomes:UP000805418};
RN [1] {ECO:0000313|EMBL:AKD44024.1}
RP NUCLEOTIDE SEQUENCE.
RA Yan S.Q., Li Y.M., Bai C.Y., Guo P.C., Si S., Sun J.H., Zhao Z.H.;
RT "Identification of cDNA sequences and alternative splicing patterns of AMEL
RT genes (AMELX and AMELY) in dog.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCAFP00845037153.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845037153.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the amelogenin family.
CC {ECO:0000256|ARBA:ARBA00010383}.
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DR EMBL; KP244310; AKD44024.1; -; mRNA.
DR RefSeq; XP_003435493.1; XM_003435445.3.
DR STRING; 9615.ENSCAFP00000017046; -.
DR PaxDb; 9615-ENSCAFP00000017046; -.
DR Ensembl; ENSCAFT00845047348.1; ENSCAFP00845037153.1; ENSCAFG00845026844.1.
DR VEuPathDB; HostDB:ENSCAFG00845026844; -.
DR eggNOG; ENOG502S4XP; Eukaryota.
DR GeneTree; ENSGT00390000009151; -.
DR HOGENOM; CLU_120753_0_0_1; -.
DR OMA; FSYENSY; -.
DR OrthoDB; 4520512at2759; -.
DR Reactome; R-CFA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-CFA-8957275; Post-translational protein phosphorylation.
DR Proteomes; UP000805418; Chromosome X.
DR Bgee; ENSCAFG00000011602; Expressed in keratinocyte and 11 other cell types or tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0030345; F:structural constituent of tooth enamel; IBA:GO_Central.
DR GO; GO:0070166; P:enamel mineralization; IBA:GO_Central.
DR InterPro; IPR004116; Amelogenin.
DR PANTHER; PTHR46794:SF2; AMELOGENIN, X ISOFORM; 1.
DR PANTHER; PTHR46794; AMELOGENIN, Y ISOFORM; 1.
DR Pfam; PF02948; Amelogenin; 1.
DR PRINTS; PR01757; AMELOGENIN.
DR SMART; SM00818; Amelogenin; 1.
PE 2: Evidence at transcript level;
KW Biomineralization {ECO:0000256|ARBA:ARBA00022591};
KW Reference proteome {ECO:0000313|Proteomes:UP000805418};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..192
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015091053"
FT REGION 97..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..176
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 192 AA; 21683 MW; EFF4ABDAEAD02CD0 CRC64;
MGTWILFACL LGAAFAMPLP PHPGHPGYIN FSYEVLTPLK WYQNMIRHPY PSYGYEPMGG
WLHHQIIPVL SQQNPSNHAL QPHHHIPMVP AQQPVVPQQP MMPVPGQHSM TPTQHHQPNL
PLPAQQPFQP QPVQPQPHQP IQPQPPVHPI QPLPPQPPLP PMFPIQPLPP MLPDLPLEAW
PATDKTKREE VD
//
