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Database: UniProt
Entry: F6PLF8_MACMU
LinkDB: F6PLF8_MACMU
Original site: F6PLF8_MACMU 
ID   F6PLF8_MACMU            Unreviewed;       203 AA.
AC   F6PLF8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-MAY-2019, entry version 57.
DE   SubName: Full=RING finger protein 152 {ECO:0000313|EMBL:EHH29333.1, ECO:0000313|Ensembl:ENSMMUP00000003263};
GN   Name=RNF152 {ECO:0000313|Ensembl:ENSMMUP00000003263};
GN   ORFNames=EGK_09734 {ECO:0000313|EMBL:EHH29333.1};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000003263, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000003263, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003263,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|EMBL:EHH29333.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CR-5 {ECO:0000313|EMBL:EHH29333.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMMUP00000003263}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003263};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; JSUE03019818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CM001270; EHH29333.1; -; Genomic_DNA.
DR   RefSeq; NP_001180763.1; NM_001193834.1.
DR   RefSeq; XP_001088933.1; XM_001088933.3.
DR   RefSeq; XP_002801001.1; XM_002800955.2.
DR   RefSeq; XP_014977603.1; XM_015122117.1.
DR   RefSeq; XP_014977604.1; XM_015122118.1.
DR   RefSeq; XP_014977605.1; XM_015122119.1.
DR   RefSeq; XP_014977606.1; XM_015122120.1.
DR   RefSeq; XP_014977607.1; XM_015122121.1.
DR   RefSeq; XP_014977608.1; XM_015122122.1.
DR   RefSeq; XP_014977609.1; XM_015122123.1.
DR   RefSeq; XP_014977610.1; XM_015122124.1.
DR   RefSeq; XP_014977611.1; XM_015122125.1.
DR   STRING; 9544.ENSMMUP00000003263; -.
DR   Ensembl; ENSMMUT00000003453; ENSMMUP00000003263; ENSMMUG00000002431.
DR   GeneID; 699091; -.
DR   KEGG; mcc:699091; -.
DR   CTD; 220441; -.
DR   eggNOG; ENOG410ITF4; Eukaryota.
DR   eggNOG; ENOG4111BNB; LUCA.
DR   GeneTree; ENSGT00730000111317; -.
DR   KO; K15705; -.
DR   OMA; SQKDLRC; -.
DR   OrthoDB; 489543at2759; -.
DR   TreeFam; TF331690; -.
DR   Proteomes; UP000006718; Chromosome 18.
DR   Bgee; ENSMMUG00000002431; Expressed in 12 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0031301; C:integral component of organelle membrane; IEA:Ensembl.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:Ensembl.
DR   GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR   GO; GO:0070936; P:protein K48-linked ubiquitination; IBA:GO_Central.
DR   GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR033609; RNF152.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR25464:SF1; PTHR25464:SF1; 1.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   TRANSMEM    166    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       12     55       RING-type. {ECO:0000259|PROSITE:PS50089}.
SQ   SEQUENCE   203 AA;  22329 MW;  7AFA570D1949FD38 CRC64;
     METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDVR CPWCRGVTKL
     PPGFSVSQLP DDPEVLAVIA IPHTSEHTPV FIKLPSNGCY MLPLPISKER ALLPGDMGCR
     LLPGSQQKSV TVVTIPAEQQ PLQGGAPQEA AEEEQDRRGV VKSSTWSGVC TVILVACVLV
     FLLGIVLHNM SCISKRFTVI SCG
//
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