ID F6PNY7_HORSE Unreviewed; 604 AA.
AC F6PNY7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Heat shock transcription factor 5 {ECO:0000313|Ensembl:ENSECAP00000015549.2};
GN Name=HSF5 {ECO:0000313|VGNC:VGNC:97706};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015549.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000015549.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015549.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000015549.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015549.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|ARBA:ARBA00006403,
CC ECO:0000256|RuleBase:RU004020}.
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DR AlphaFoldDB; F6PNY7; -.
DR STRING; 9796.ENSECAP00000015549; -.
DR PaxDb; 9796-ENSECAP00000015549; -.
DR Ensembl; ENSECAT00000019019.3; ENSECAP00000015549.2; ENSECAG00000017983.3.
DR VGNC; VGNC:97706; HSF5.
DR GeneTree; ENSGT00510000048674; -.
DR HOGENOM; CLU_037490_0_0_1; -.
DR InParanoid; F6PNY7; -.
DR OMA; HRIWQNS; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000017983; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015:SF278; HEAT SHOCK FACTOR PROTEIN 5; 1.
DR PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 11..132
FT /note="HSF-type DNA-binding"
FT /evidence="ECO:0000259|SMART:SM00415"
FT REGION 168..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..189
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 65609 MW; A767060DF435B549 CRC64;
MEEALLSTPI NPNNFPAKLW RLVNSPRYRS IRWDGRGEGL LIDQPLFEAE LLSPPGAGAG
GGGGGVGGSG AEPELFKTTN FTSFIRQLNL YGFRKVVLGG PGAAGPGPGP GAAGRPHFRR
DQPQLLVHLK RLTSANKAKL AAGLEVPCRP PNRFQRLLIT SASASASACT SPLQHQEPAP
PPAGPRPEPH GPVAVGQFHR SFRRDGLSPY SYVSTSSHNH STFPLKGLDR TSIPPRTWQN
SLGMHPGQVE TPPTFSDKGV PFPVLQRFPT EVTYTLQPSA TSVHVQQSPQ TMVSSSQKYS
NYTPSAQYSQ AYYPTAVLQC CSPSTHMDAL SSCVTPTASS YAHCNYFQNP PMQSSYPVEF
LPSNWPCSAT DENKKTEVNL EAVFQIVDEL HSSPKLEMVK VEPVENQCPT SQSNRGQHIL
TNSNNSNPSS TSQASQLEPL TPVGSDITSF VVGTEQAITC SLPQSPEYIY TIHTAQPVEN
TTMQESAGIQ QARVKLKEQL SHNPSPTSVV FVQEGLPFST HQVDASIKCQ TNPPENILPS
EQMGFLISEM GPASKPSKDT GLSTPARYRE RRSNSQQGKS PDLHLLVDVA CKQEHFPKEE
ELKE
//
