ID F6PPD0_HORSE Unreviewed; 493 AA.
AC F6PPD0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Amyloid beta protein binding family B member 3 {ECO:0000313|Ensembl:ENSECAP00000003560.2};
GN Name=APBB3 {ECO:0000313|Ensembl:ENSECAP00000003560.2,
GN ECO:0000313|VGNC:VGNC:49367};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003560.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000003560.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003560.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000003560.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003560.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6PPD0; -.
DR Ensembl; ENSECAT00000005085.4; ENSECAP00000003560.2; ENSECAG00000003436.4.
DR VGNC; VGNC:49367; APBB3.
DR GeneTree; ENSGT00390000000002; -.
DR HOGENOM; CLU_021196_0_0_1; -.
DR OrthoDB; 5404780at2759; -.
DR Proteomes; UP000002281; Chromosome 14.
DR Bgee; ENSECAG00000003436; Expressed in trophectoderm and 23 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:Ensembl.
DR GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
DR CDD; cd01272; PTB1_Fe65; 1.
DR CDD; cd01271; PTB2_Fe65; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039576; APBB1/2/3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14058; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B; 1.
DR PANTHER; PTHR14058:SF10; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00462; PTB; 2.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01179; PID; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 29..61
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 119..261
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 297..422
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 56..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 53198 MW; 7FB2F078C4985390 CRC64;
MLGKDYMLAI ILVNCDDDLW GDQSLEGEPG LPPGWRKIHD AAGTYYWHVP SGSTQWQRPT
WEPGDAEDPG TRTEGIWGLR PPKGRSFSSL ESSLDQSNSL SWYGEESYIQ SVEPGAKCFA
VRSLGWVEVP EEDLVPGKSS IAVNNCIQQL AQTRSQSQSP DGAWGEGQNM LMILKKDAMS
LVNPLDHSLI HCQPLVHIRV WGVGSSKGRD SPISDPARDF AFVAGDKDSC MLKCHVFRCD
VPAKAVASAL HGLCAQILSE RVGVSSDSPC CSLDPISPED LPRQVELLDA VSQAAQKYEA
LYMGTLPVTK AMGMDVLNEA IGTLTTRGDR DAWVPAMLSV SDSLMTAHPI QAEAGAEEEP
LWQCLVRLVT FIGVGHDPHT FGLIADLGRQ SFQCAAFWCQ PHAGGLSEAV QAACMVQYQK
CLVASAARGK AWGAQARARL RLKRTSSVDS PGGPLPLPLL KGGVGGAGAA PRKRGVFSFL
DAFRLKPSLL HMP
//
