ID F6PPW0_MONDO Unreviewed; 800 AA.
AC F6PPW0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=ITGB5 {ECO:0000313|Ensembl:ENSMODP00000022896.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000022896.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000022896.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000022896.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR RefSeq; XP_007493880.1; XM_007493818.2.
DR AlphaFoldDB; F6PPW0; -.
DR STRING; 13616.ENSMODP00000022896; -.
DR Ensembl; ENSMODT00000023301.4; ENSMODP00000022896.3; ENSMODG00000018360.4.
DR GeneID; 100020074; -.
DR KEGG; mdo:100020074; -.
DR CTD; 3693; -.
DR eggNOG; KOG1226; Eukaryota.
DR GeneTree; ENSGT01090000259987; -.
DR HOGENOM; CLU_011772_0_1_1; -.
DR InParanoid; F6PPW0; -.
DR OMA; CVMLFTY; -.
DR OrthoDB; 5475862at2759; -.
DR TreeFam; TF105392; -.
DR Proteomes; UP000002280; Chromosome 4.
DR Bgee; ENSMODG00000018360; Expressed in heart and 18 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0034684; C:integrin alphav-beta5 complex; IEA:Ensembl.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0090136; P:epithelial cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0043149; P:stress fiber assembly; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF26; INTEGRIN BETA-5; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..800
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003344212"
FT TRANSMEM 721..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..76
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 35..463
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 635..720
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 744..791
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT DISULFID 36..46
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 39..75
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 49..64
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 202..211
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 259..300
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 401..413
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 433..683
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 461..465
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 484..522
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 489..498
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 500..513
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 528..533
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 530..563
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 535..548
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 550..555
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 569..574
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 571..602
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 576..585
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 587..594
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 608..613
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 610..658
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 615..625
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 628..631
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 635..644
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 641..715
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 662..691
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 800 AA; 88568 MW; A1B3034862EC3A9D CRC64;
MFRRLWSLSS CFLVFCTLLP QSPGLNICTS GSATSCEECL LINPKCAWCS KEDFGNQRSV
TSRCDLKANL LKLGCGGELE SPDSSITVLK NLPLSIKGSS PSNADVIQMT PQKISMNLRP
GDKTPFRVQV RQVEDYPVDL YYLMDLSLSM KDDLDTILNL GTKLAEEMRK LTSNFRLGFG
SFVDKNISPF SYTAPRYQTN PCIGYKLFPY CVPSFGFRHL LSLTDKVDSF NEEVKKQMVS
RNKDAPEGGF DAILQAAVCK EKIGWRKEAL HLLVFTSDDV PHIALDGKLG GLVQPHDGQC
HLNEANEYTA SKQMDYPSLA LLGEKLAENN IHLIFAVTKN HYMLYKNFTA LIPGTTVEIL
HADSRNIIQL IVNAYNSIRS KVELSVWDNP EDLGLSFTAT CQDGLSYPGQ RKCGDLKIGE
TVSFEVSVEA RSCPSPDTVH TFTLRPVGFR DALELVVTYN CSCNCASRTE QDSPRCSGNG
TYTCGTCECH PSYLGSKCEC QEGENRDLYQ NLCREAEGKP LCSGRGECSC NQCSCYESEF
GKIYGPFCEC DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTE TETCLSNDGQ
ICSGRGYCSC GRCQCIKPGA FGETCEKCPT CPDACSTKRD CVECMLFNSG RLADNQTCQK
HCRDEVIIQV DSIMKDDQEA VLCFYKTAKD CVMMFTYSEL PSGKSKLMVL KEPECGSAPS
AMTILLAVVG SILLVGIALL AIWKLLVTIH DRREFAKFQS ERSRARYEMA SNPLYRKPIS
THTVDFTFNK LNKSYNGTVD
//
