ID F6PSF7_HORSE Unreviewed; 224 AA.
AC F6PSF7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Triggering receptor expressed on myeloid cells 1 {ECO:0000313|Ensembl:ENSECAP00000015014.3};
GN Name=TREM1 {ECO:0000313|Ensembl:ENSECAP00000015014.3,
GN ECO:0000313|VGNC:VGNC:24481};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015014.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000015014.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015014.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000015014.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015014.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_001501031.1; XM_001500981.4.
DR AlphaFoldDB; F6PSF7; -.
DR STRING; 9796.ENSECAP00000015014; -.
DR PaxDb; 9796-ENSECAP00000015014; -.
DR Ensembl; ENSECAT00000018405.4; ENSECAP00000015014.3; ENSECAG00000017436.4.
DR GeneID; 100054285; -.
DR KEGG; ecb:100054285; -.
DR VGNC; VGNC:24481; TREM1.
DR GeneTree; ENSGT00470000042299; -.
DR InParanoid; F6PSF7; -.
DR OMA; MTDIIRV; -.
DR TreeFam; TF339293; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000017436; Expressed in blood and 20 other cell types or tissues.
DR ExpressionAtlas; F6PSF7; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070945; P:neutrophil-mediated killing of gram-negative bacterium; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR19357; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; 1.
DR PANTHER; PTHR19357:SF0; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..224
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040404569"
FT TRANSMEM 191..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..129
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 132..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 224 AA; 24418 MW; 62B1515F052BB2CB CRC64;
MRKAKLWGLL GMLFVSELQA AAGQAEEKKI LTEGETLNYH CVYTRKHSQS QKAWQRVMDG
GKAETLAFTE KTSKNSQELG GRYFLEDNTT QGAVHVRMTN VQMSDSGLYR CVIYPILSNP
EVLESLRLVV TKGPSDSPSP DKNPPRDKAQ TTTFPPATKA PVTQPPPKST AGVSRPGLEV
NPTHVTDVTR ISVFSIVIPV ACALVTKSLV LTVLFAVTQK SFGS
//
