ID F6PUK4_HORSE Unreviewed; 338 AA.
AC F6PUK4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Myelin protein zero like 3 {ECO:0000313|Ensembl:ENSECAP00000008629.3};
GN Name=MPZL3 {ECO:0000313|VGNC:VGNC:20303};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008629.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000008629.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008629.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000008629.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008629.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6PUK4; -.
DR STRING; 9796.ENSECAP00000008629; -.
DR PaxDb; 9796-ENSECAP00000008629; -.
DR Ensembl; ENSECAT00000011086.4; ENSECAP00000008629.3; ENSECAG00000010748.4.
DR VGNC; VGNC:20303; MPZL3.
DR GeneTree; ENSGT01030000234556; -.
DR HOGENOM; CLU_090350_1_0_1; -.
DR InParanoid; F6PUK4; -.
DR OMA; WCLNCVD; -.
DR TreeFam; TF331728; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000010748; Expressed in zone of skin and 23 other cell types or tissues.
DR ExpressionAtlas; F6PUK4; baseline.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0042633; P:hair cycle; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000920; Myelin_P0-rel.
DR PANTHER; PTHR13869; MYELIN P0 RELATED; 1.
DR PANTHER; PTHR13869:SF20; MYELIN PROTEIN ZERO-LIKE PROTEIN 3; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR00213; MYELINP0.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..338
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040436314"
FT TRANSMEM 259..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 149..252
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 79..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 338 AA; 36697 MW; 741242E8D980FC74 CRC64;
MFLWQLSIAI LRVLAASRPD VTSGVTCVVT GSRKQGVQAS GERSRCSRAE RREAAAALCS
HCWQSCSFRV SAPAGSAPLP AGGAVREDGR SSASGWGVSG KPPRRFWEGK KQEGVRSGSF
TLQLCCAWGV CIVVSLEIKA DAHVRGYVGE KIKLKCTFRS TSSVTDKLTI DWTYRPPSSS
RTESIFHYQS FQYPTTAGTF RDRISWVGDV YKGDASISIS DPTIRDNGTF SCAVKNPPDV
HHNIPLTELT VTERGFGTML SSVALLSILV FIPSAAVVVL LLVRMGRKSA GLKKRGKSGY
KKSSIEVSDD TDQDEDGCMA RLCVRCAECL DSDSEEIY
//
