ID F6PVG7_CALJA Unreviewed; 734 AA.
AC F6PVG7; U3F5T0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=BCAR3 adaptor protein, NSP family member {ECO:0000313|Ensembl:ENSCJAP00000033014.2};
DE SubName: Full=Breast cancer anti-estrogen resistance protein 3 isoform 2 {ECO:0000313|EMBL:JAB30385.1};
GN Name=BCAR3 {ECO:0000313|EMBL:JAB30385.1,
GN ECO:0000313|Ensembl:ENSCJAP00000033014.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000033014.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000033014.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB30385.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebral cortex {ECO:0000313|EMBL:JAB30385.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000033014.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; GAMR01003547; JAB30385.1; -; mRNA.
DR RefSeq; XP_008999982.1; XM_009001734.2.
DR Ensembl; ENSCJAT00000034887.4; ENSCJAP00000033014.2; ENSCJAG00000017873.5.
DR GeneTree; ENSGT00940000154130; -.
DR HOGENOM; CLU_015281_0_0_1; -.
DR OrthoDB; 2953960at2759; -.
DR Proteomes; UP000008225; Chromosome 7.
DR Bgee; ENSCJAG00000017873; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 63..162
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 457..727
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 294..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 82515 MW; CF4E1292BBD885BA CRC64;
MPKECNAFHA LSAALCCFYH RKSFIGVKFS KERHMMDRTP ERLKKELEEE LLLSSEDLRS
HAWYHGRIPR QVSENLVQRD GDFLVRDSLS SPGNFVLTCQ WKNLAQHFKI NRTVLRLSEA
YSRVQYQFEM ESFDSIPGLV RCYVGNRRPI SQHSGAIIFQ PINRTVPLRC LEERYGTSSG
RAQEGSLTEG RPDVAKRLSL TMGGVQTREQ NLPRGNLLRN KEKSGSQPAC LDHMQDRRAL
SLKAHQSESY LPIGCKLPPQ SSGVDTSPCP NSPVFRTGSE PALSPAVVRR VSSDARAGEA
LRGSDSQLCP KPPPKPCKVP LLKAPSSPSA WLNSEANYCE LNPAFATGCS RAAKLPLCAQ
GSRTELLTAR QNGVPGPRNS GINYLILDGD DRERPWEPVA TQMEEGQWDK GKFVTPLLET
VSSFRPNDFE SKLLPPENKP LETAMLKRAK EVFTNSNPKI IAQHILSMDC KVARILEVSE
EMKRNMGVSS GLELITLPHG HQLRLDIIER HNTMAMGIAV DILGCTSTLD ERAATLSKII
QVAVELKDSM GDLYSFSALM KALEMPQITR LEKMWTALRH QYTQTAILYE KQLKPFSKIL
HEGRESTCVP PSNVSVPLLM PLVTLMERQA VTFEGTDMWE KNDQSCEIML NHLATARFMA
QTADSYRMNA EMNLAGFQPD EEMNEICKTE FQMRLLWGSK GAQVNQTERY EKFNQILTAL
SRKLEPPPVK QAEL
//
