ID F6PWH0_CALJA Unreviewed; 358 AA.
AC F6PWH0; F6PWB9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Septin {ECO:0000256|PIRNR:PIRNR006698};
GN Name=SEPT12 {ECO:0000313|EMBL:JAB46257.1};
GN Synonyms=SEPTIN12 {ECO:0000313|Ensembl:ENSCJAP00000036995.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB46257.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000036995.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB46257.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB02161.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB46257.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB23328.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB15164.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000036995.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Filament-forming cytoskeletal GTPase.
CC {ECO:0000256|PIRNR:PIRNR006698}.
CC -!- SUBUNIT: Septins polymerize into heterooligomeric protein complexes
CC that form filaments. {ECO:0000256|PIRNR:PIRNR006698}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|PIRNR:PIRNR006698, ECO:0000256|RuleBase:RU004560}.
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DR EMBL; GAMT01009700; JAB02161.1; -; mRNA.
DR EMBL; GAMS01007972; JAB15164.1; -; mRNA.
DR EMBL; GAMR01010604; JAB23328.1; -; mRNA.
DR EMBL; GAMP01006498; JAB46257.1; -; mRNA.
DR RefSeq; XP_009007361.1; XM_009009113.2.
DR RefSeq; XP_009007363.1; XM_009009115.2.
DR STRING; 9483.ENSCJAP00000036995; -.
DR Ensembl; ENSCJAT00000039072.5; ENSCJAP00000036995.5; ENSCJAG00000019889.5.
DR eggNOG; KOG1547; Eukaryota.
DR GeneTree; ENSGT00940000158310; -.
DR HOGENOM; CLU_017718_7_1_1; -.
DR OMA; AHCEFLL; -.
DR OrthoDB; 5396944at2759; -.
DR TreeFam; TF101078; -.
DR Proteomes; UP000008225; Chromosome 12.
DR Bgee; ENSCJAG00000019889; Expressed in kidney and 6 other cell types or tissues.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0031105; C:septin complex; IEA:Ensembl.
DR GO; GO:0097227; C:sperm annulus; IEA:Ensembl.
DR GO; GO:0005819; C:spindle; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF66; SEPTIN-12; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006698};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR006698};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 46..317
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 40980 MW; F511FA12BD58A1AB CRC64;
MEPLRHSPSP CSSSRPSSPS TPPCEMPGPV GVEAVLEQLK IKAMKMGFEF NIMVVGQSGL
GKSTMLNTLF KSKVWKSNLP GLKVPIPQTL QLHSVTHVIE EKGVKLKLTV IDTPGFGDQI
NNDKCWDPIL GYINEQYERY LQEEILITRQ RHIPDTRVHC CVYFVPPTGH CLRPLDIEFL
QRLCQTVNVV PVIARADSLT MEERETFRRR IQQNLRTHCI EVYPQKCLDE DINDKILNSK
LRERIPFAVV GADQQHLVNG RCVLGRKTKW GVIEVENMAH CEFPLLRDLL IRSHLQDLKD
ITHNVHYENY RIIRLNESHL LPRGPGWVNL APASPGQLTS HQPFKICREA HKDSEKEF
//
