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Database: UniProt
Entry: F6PZ77_HORSE
LinkDB: F6PZ77_HORSE
Original site: F6PZ77_HORSE 
ID   F6PZ77_HORSE            Unreviewed;       637 AA.
AC   F6PZ77;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   08-MAY-2019, entry version 48.
DE   SubName: Full=Electron transfer flavoprotein dehydrogenase {ECO:0000313|Ensembl:ENSECAP00000010444};
GN   Name=ETFDH {ECO:0000313|Ensembl:ENSECAP00000010444,
GN   ECO:0000313|VGNC:VGNC:17696};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010444, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000010444, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010444,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000010444}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010444};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   PaxDb; F6PZ77; -.
DR   Ensembl; ENSECAT00000013185; ENSECAP00000010444; ENSECAG00000012304.
DR   KEGG; ecb:100061849; -.
DR   CTD; 2110; -.
DR   VGNC; VGNC:17696; ETFDH.
DR   eggNOG; KOG2415; Eukaryota.
DR   eggNOG; COG0644; LUCA.
DR   GeneTree; ENSGT00390000010773; -.
DR   InParanoid; F6PZ77; -.
DR   KO; K00311; -.
DR   OMA; NMRPSFH; -.
DR   OrthoDB; 293434at2759; -.
DR   TreeFam; TF105687; -.
DR   Proteomes; UP000002281; Chromosome 2.
DR   Bgee; ENSECAG00000012304; Expressed in 3 organ(s), highest expression level in liver.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR   GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR   GO; GO:0004174; F:electron-transferring-flavoprotein dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0043783; F:oxidoreductase activity, oxidizing metal ions with flavin as acceptor; IBA:GO_Central.
DR   GO; GO:0048039; F:ubiquinone binding; IBA:GO_Central.
DR   GO; GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IEA:Ensembl.
DR   GO; GO:0022904; P:respiratory electron transport chain; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR040156; ETF-QO.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR10617; PTHR10617; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    480    498       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      597    626       4Fe-4S ferredoxin-type.
FT                                {ECO:0000259|PROSITE:PS51379}.
SQ   SEQUENCE   637 AA;  70761 MW;  34BCA784A5399024 CRC64;
     MSAVLILSEY EQVSKCISKG ITWNHAISGQ EAYQCFHALK IKKDYLPLCA TRWSSTSVVP
     RITTHYTVCP RDKDKRWEGV NMERFAEEAD VVIVGAGPAG LSAAIRLKQL ATKQEKDIRV
     CLVEKAAQIG AHTLSGACLD PCGFEELFPD WKEKGAPLNT PVTEDRFGIL TEKYRIPVPI
     LPGLPMNNHG NYIVRLGHLV SWMGEQAESL GVEVYPGYAA AEVLFHEDGS VKGVATNDVG
     IQKDGAPKTT FERGLELHAK VTIFAEGCHG HLAKQLYKKF DLRANCEPQT YGIGLKELWL
     IDEKKWKPGR VDHTVGWPLD RHTYGGSFLY HLNEGEPLIA LGFVVGLDYQ NPYLSPFREF
     QRWKHHPSIQ PTLEGGKRIA YGARALNEGG LQSIPKLTFP GGLLIGCSPG FMNVPKIKGT
     HTAMKSGILA AESIFNQLTS ENLQSKTTGL HVTEYEDNLK KSWVWKELYT VRNIRPSCHG
     ILGVYGGMIY TGIFYWIFRG MEPWTLKHKG SDSDQLKPAK DCTPIEYPKP DGQISFDLLS
     SVALSGTNHE HDQPAHLTLK DDSIPVNRNL SIYDGPEQRF CPAGVYEFVP LEQGDGFRLQ
     INAQNCVHCK TCDIKDPSQN INWVVPEGGG GPAYNGM
//
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