ID F6PZD1_HORSE Unreviewed; 552 AA.
AC F6PZD1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Serine protease 53 {ECO:0000313|Ensembl:ENSECAP00000022418.3};
GN Name=PRSS53 {ECO:0000313|VGNC:VGNC:21921};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022418.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000022418.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022418.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000022418.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022418.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6PZD1; -.
DR SMR; F6PZD1; -.
DR STRING; 9796.ENSECAP00000022418; -.
DR MEROPS; S01.374; -.
DR PaxDb; 9796-ENSECAP00000022418; -.
DR Ensembl; ENSECAT00000026826.4; ENSECAP00000022418.3; ENSECAG00000024871.4.
DR VGNC; VGNC:21921; PRSS53.
DR GeneTree; ENSGT00940000162122; -.
DR HOGENOM; CLU_004497_4_0_1; -.
DR InParanoid; F6PZD1; -.
DR OMA; TSSCAQE; -.
DR TreeFam; TF321170; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000024871; Expressed in liver and 22 other cell types or tissues.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24253:SF100; POLYSERASE-2; 1.
DR PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR Pfam; PF00089; Trypsin; 2.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
DR PROSITE; PS50240; TRYPSIN_DOM; 2.
DR PROSITE; PS00134; TRYPSIN_HIS; 2.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..552
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023927581"
FT DOMAIN 11..273
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 294..525
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 552 AA; 58490 MW; 7AB4B75A09824ACB CRC64;
MKQSWGSGLL ILGAVVLTEG LQAAQCACGQ RGPGPPEPQE GNTVAGEWPW QASVRRQGVH
VCSGSLVAGT WVLTAAHCFE KAAMTELNSW SVVLGSLQRE GLSPGAEEVG VTALQLPRAY
NHYSQGSDLA LLQLAHPVAH TPLCLPQPAH RFPFGTSCWA TGWDQDTSDA PRTLRNLRLR
LISRPTCNCL YNRLHQRLLA SPARPGMLCG GAQPGVQGPC QGDSGGPVLC REPDGHWVQA
GIISFASNCA QEDTPVLLTD MAAHSSWLQA RAQGAAFLAQ NPETLEISDE DSCVACGSLR
REGPQAGAPS QWPWDARLIH QGKLACGGAL ISEEVVLTAA HCFIGRQTPE EWSVGLGSGP
EEWGLKQLIL HGAYTHPEGG YDVALLLLAQ PVTLGPSLRP LCLPYTDHRL PDGERGWVLG
LAQGAGTSSP QAVPVTLLGP RACSRLHTTL GSHGITILPG MVCTSVVGEP PHCEGLSGAP
LVHEVRGTWF LAGLHSFGDA CQGPARPAVF TALPAYEKWV SSLDWQVYFA EEPEPEADTG
SCLANRSQPA GC
//
