ID F6Q1D5_XENTR Unreviewed; 376 AA.
AC F6Q1D5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=ALX homeobox 4 {ECO:0000313|Ensembl:ENSXETP00000016438};
DE SubName: Full=Homeobox protein aristaless-like 4 {ECO:0000313|RefSeq:XP_004913406.1};
GN Name=alx4 {ECO:0000313|Ensembl:ENSXETP00000016438,
GN ECO:0000313|RefSeq:XP_004913406.1,
GN ECO:0000313|Xenbase:XB-GENE-853003};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000016438};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000016438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000016438};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000016438}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_004913406.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_004913406.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_004913406.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_004913406.1; XM_004913349.4.
DR Ensembl; ENSXETT00000016438; ENSXETP00000016438; ENSXETG00000007545.
DR Ensembl; ENSXETT00000105326; ENSXETP00000116281; ENSXETG00000007545.
DR GeneID; 100493396; -.
DR KEGG; xtr:100493396; -.
DR AGR; Xenbase:XB-GENE-853003; -.
DR CTD; 60529; -.
DR Xenbase; XB-GENE-853003; alx4.
DR OMA; PCYGKDN; -.
DR OrthoDB; 5400675at2759; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Bgee; ENSXETG00000007545; Expressed in neurula embryo and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR PANTHER; PTHR24329:SF322; HOMEOBOX PROTEIN ARISTALESS-LIKE 4; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 179..239
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 356..369
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 181..240
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 47..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 41332 MW; 144DA483AF50407C CRC64;
MNADPCVSYC DPPAMDCYYS PAPQGRELQT SPFRAFQPSD KFSPVFLASK GQGFGDKSRG
SFQQECQSLD ANVQSNSGEQ QGSFTKYQAH HPSHQQQQSH LYMQSTPCKS PSDSLKVQDS
PGDPLIPCYA KESALTPNSD HQGMDSGYIT SKETAGKGSQ DRGSGDLPMD KTESESNKGK
KRRNRTTFTS YQLEELEKVF QKTHYPDVYA REQLAMRTDL TEARVQVWFQ NRRAKWRKRE
RFGQMQQVRT HFSSAYELPL LTRAENYAQI QNPSWIGNNG GGSPVPACVV PCDTVSSCMS
PHSHPHSAGG VSEFLSVPGP GAHVGQTHMG GLFGSAAMGP GINGYDLNTE PDRKSSSIAA
LRMKAKEHSA AMSWAT
//
