ID F6Q1G5_HORSE Unreviewed; 1139 AA.
AC F6Q1G5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Interphotoreceptor matrix proteoglycan 2 {ECO:0000313|Ensembl:ENSECAP00000018964.3};
GN Name=IMPG2 {ECO:0000313|Ensembl:ENSECAP00000018964.3,
GN ECO:0000313|VGNC:VGNC:19055};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018964.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018964.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018964.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018964.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018964.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, interphotoreceptor matrix {ECO:0000256|ARBA:ARBA00004593}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSECAT00000022918.3; ENSECAP00000018964.3; ENSECAG00000021288.4.
DR VGNC; VGNC:19055; IMPG2.
DR GeneTree; ENSGT00530000063503; -.
DR TreeFam; TF331340; -.
DR Proteomes; UP000002281; Chromosome 19.
DR Bgee; ENSECAG00000021288; Expressed in retina and 23 other cell types or tissues.
DR ExpressionAtlas; F6Q1G5; baseline.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0033165; C:interphotoreceptor matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.30.70.960; SEA domain; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR039861; IMPG.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR12199; INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN; 1.
DR PANTHER; PTHR12199:SF4; INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN 2; 1.
DR Pfam; PF01390; SEA; 2.
DR SMART; SM00200; SEA; 2.
DR SUPFAM; SSF82671; SEA domain; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50024; SEA; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1002..1026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 128..242
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 799..912
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 912..953
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 319..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 921..938
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1139 AA; 126299 MW; 68C0C5A563BB9C9E CRC64;
MCQEAVWEAF RTFWDRLPGR EEYRYWMNLC EDGVTTILEM ATNFSESVEH RSLIMKKLTY
TKEPVSSLEL SSPVPVGDTS TLGGAVLSVP YPEMTSYEGA WESSLERPEE SISNEIENVI
EEPTKAAAEQ IAEFSVHLTG EQYKEELQDP SSFYHQHLVE EFISEVENAF SGLPGYKGIR
VLDFRSPKDN GSGIDVHYAV TFNGEAISNT TWDLISLHSN KVENHGLVEL DDKPTAVYTI
SNFRDYIAET LHQNFLLGNS SLNPDPDSLQ LINVRGVLLP QTEDLVWNTQ RSSLQATPPS
ILDNTLQAEW LSADESTTRS VSPLDFSSGP PSATGRERWS ESPGGDLMST PKLAFSSKVG
LSSSVGVLEV SSLTLDSVTT AALQTGLPVA SEERTSGSYL LGDGLTEVEE LEDFLSIDPL
PSGSFTHPVP KETVPSMEDS GVSLTSSPYQ VSSVTLDLLD KEITTPFGLD SLTSKVKGQL
EVSTLMPDIS MDKEFIFESG LGSGSGQKVN LITWPWSETS PEKSTEPLSK SWLEDGDSLL
PTEDVDERLG IDDKIDSTHQ SIEHSEYGDF DRSPSFVEEE PLGGPAVPIF AAETTTQSAS
LILSKHTSEI SDVDHYSITK APPPLTSTAI SASTDKPDQV EPFLKEDMEQ TTESSNSEWF
DSKVSVVKPS MQPLWTTLPE SEVVWAKTSS PEKLSRDTLA GTPQSTDKLW LKASVTQSAK
LPPTTSSTLL EDEVIMGVQD ISLELDHMGT GYYQPELIPE ENGKAGSYME MSTNVHSTEL
AIVAWPTKGG DLSHNQTTGA LVVFFSLRVT NMMFSEDLFN KNSLEYKALE QRFLELLVPY
LQSNLTGFQN LEILNFRNGS VVVNSRVKFA KSVPRNVNNA VYMILEDFCT TAYQTMNLAI
DKYSLDVESG DQANPCKFQA CNEFSECLVN PWSGEAECRC YPGYQSVKEL PCQSLCDLQP
DFCLNDGKCD IIPGHGAICR CRVGDNWWYR GEHCEEFVSE PWVIGIAVAS LVGLLLISSA
VVFVLVKMLQ AQYVRRERER PFRQPDSLSS IENAVKSNPV YERRVVGLEQ CRGAYPQHPF
CSSAGGEVMG GLSREEIRQM YENSELSREE IQERMRILEL YASDPKFAAF VRQHQMEKL
//