ID F6Q277_HORSE Unreviewed; 1276 AA.
AC F6Q277;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Neurofascin {ECO:0000313|Ensembl:ENSECAP00000010925.3};
GN Name=NFASC {ECO:0000313|Ensembl:ENSECAP00000010925.3,
GN ECO:0000313|VGNC:VGNC:20701};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010925.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010925.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010925.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010925.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010925.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR Ensembl; ENSECAT00000013738.3; ENSECAP00000010925.3; ENSECAG00000011985.4.
DR VGNC; VGNC:20701; NFASC.
DR GeneTree; ENSGT00940000157024; -.
DR HOGENOM; CLU_005756_1_1_1; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000011985; Expressed in spinal cord and 13 other cell types or tissues.
DR ExpressionAtlas; F6Q277; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR CDD; cd05845; IgI_2_L1-CAM_like; 1.
DR CDD; cd05875; IgI_hNeurofascin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR InterPro; IPR026965; NFASC_Ig-like.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1146..1167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 137..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 239..326
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 357..445
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 450..537
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 542..630
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 634..716
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 728..823
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 828..921
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 926..1028
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1032..1128
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1177..1201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1247..1261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 142495 MW; 353AB02B3819BE11 CRC64;
MRRLAARGAA GDAGEVAAPA ADSTHCAQGR SPSPPRLIDV CAIWDTGVLP PTADWKGASS
GVAGARLNEA ETLSSIQEAQ LERLEVATPC GPGSRERGPV LRMARQQLPP WVHAAILLCL
LSLGRAIEIP MDLSQPPTIT KQSVKDHIVD PRDNILIECE AKGNPAPSFH WTRNSRFFNI
AKDPRVSMKR RSGTLVIDFR SGGRPEEYEG EYQCFARNKF GTALSNRIRL QVSKSPLWPK
ENLDPVVVQE GAPLTLQCNP PPGLPSPVIF WMSSTMDPIT QDKRVSQGHN GDLYFSNVML
QDMQTDYSCN ARFHFTHTIQ QKNAFTLKVL TNHPHNDSSL RNHPDMYSAR GVAERTPSFM
YPQGTASSQM VLRGMDLLLE CIASGVPTPD IAWYKKGGDL PSDKAKFENF NKALRITNVS
EEDSGEYFCL ASNKMGSIRH TISVRVKAAP YWLDEPKNLI LAPGEDGRLV CRASGNPKPT
IQWMVNGEPL QSAPPNPNRE VAGDTIIFRD TQISSRAVYQ CNTSNEHGYL LANAFVSVLD
VPPRMLSPRN QLIRVILYNR TRLDCPFFGS PIPTLRWFKN GQGSNLDGGN YHVYENGSLE
IKMIHKEDQG IYTCVATNIL GKAENQVRLE VKDPTRIFRM PEDQVAKRGT TVQLECRVKH
DPSLKLTVSW LKDDEPLYIG NRMKKEDDSL TIFGVAERDQ GSYTCVASTE LDQDLAKAYL
TVLGRPDRPR DLELTDLAER SVRLTWIPGD DNNSPITDYV VQFEEDQFQP GVWHDHSKFP
GSVNSAVLQL SPYVNYQFRV IAINEVGSSH PSLPSERYRT SGAPPESNPA DVKGEGTRKN
NMEITWTPMN ATSAFGPNLR YIVKWRRRET RESWNNVTVW GSRYVVGQTP VYVPYEIRVQ
AENDFGKGPE PDTVIGYSGE DYPRAAPTDV KIRVLNSTAI SLQWNRVYSD TVQGLLREYR
AYYWRESSLL KSLWVSQKRQ QASFPGDRLR GVVPRLFPYS NYKLEMVVVN GRGDGPRSET
KEFTTPEGVP SAPRRFRVRQ PNLETINLEW DHPEHPNGIL TGYTLRYVPF NGTKVGKQIV
ENFSPNQTKF TVQRADPVSR YRFTLSARTQ VGSGEAVTEE SPAPPNEATP TAAYTNNQAD
IATQGWFIGL MCAIALLVLI LLIVCFIKRS RGGKYPVREK KDVPLGPEDP KEEDGSFDYS
DEDNKPLQGS QTSLDGTIKQ QESDDSLVDY GEGGEGQFNE DGSFIGQYTV KKDKEETEGN
ESSEATSPVN AIYSLA
//
