ID F6Q4K5_HORSE Unreviewed; 1638 AA.
AC F6Q4K5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Coiled-coil and C2 domain containing 2A {ECO:0000313|Ensembl:ENSECAP00000022691.4};
GN Name=CC2D2A {ECO:0000313|Ensembl:ENSECAP00000022691.4,
GN ECO:0000313|VGNC:VGNC:16103};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022691.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000022691.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022691.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000022691.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022691.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000027124.4; ENSECAP00000022691.4; ENSECAG00000025115.4.
DR VGNC; VGNC:16103; CC2D2A.
DR GeneTree; ENSGT00940000155482; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000025115; Expressed in oviduct epithelium and 21 other cell types or tissues.
DR ExpressionAtlas; F6Q4K5; baseline.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR028928; CC2D2AN-C2.
DR InterPro; IPR041510; DUF5523.
DR PANTHER; PTHR20837; CENTROSOMAL PROTEIN-RELATED; 1.
DR PANTHER; PTHR20837:SF7; COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A; 1.
DR Pfam; PF15625; CC2D2AN-C2; 1.
DR Pfam; PF17661; DUF5523; 2.
DR SMART; SM00239; C2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 1060..1220
FT /note="C2"
FT /evidence="ECO:0000259|SMART:SM00239"
FT REGION 15..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 458..519
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 567..598
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 15..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..246
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1638 AA; 187900 MW; 81C1ECF8957896B0 CRC64;
MNPQEEKVKI ITEEFVENDE DADVGRQKTS RVQRRKRKKQ LPTAGPDEMV SEKSHLGDQQ
EPGHEDPNAD ARPLSMPTRR GPRSLPPIPS ASRTGFAEFS MRERMREKLQ AARSKAESAL
LQEIPTPRPR RLRSPSEKEL ETEFGTEPGG KIQTTQQEDD SQSYSRVKFR DSVRKIKSKT
PVPPGFPSAE EAYNFFTFNF DPEPEESEEK PKAKNRDGAN QEEGEGEEEE APVPEGIDKT
DEEELLDDKD AVDFLLGLDR GAEDIVAVRP ADYESVHIRL QKEKELLFIP SRRTVPTYKK
LPENVQPRFL EDEGLYIGAR LEVPRTNQNI MENRLLMQEP VSAQPLLPSG APEQLREGRR
WFGDDGRILA LPNPIKPFPS RPLVLSQEQD IKAELETLYK KAVKYVHRSQ HMIGSGDPPG
NFQLDIDISG LIFTHHPCFS REHVLAAKLA QLYDQYLARR QRNKAKFLTD KLQALRNAVQ
MSLNPAKTPK SLDTTRRAIN EYKSEIRQTR KLRDIEQEKD RTLLKTIIKV WKEMKSLREF
QRFTNTPLKL VLRKEKVDQK ADEEAYEAEV QAEISELLEE HREEYEQRMD EYRSAHQQWK
AWKKAQRTKK KKKKQGVEEH PDDEMEEPYP GEDPVKPVPP EPTNQAVIEQ EVRERAAQSR
RRPGEPMLVP ELSLAGSVTP NDQCPRVEVL RREDVKRRSV YLKVLFNDKE VSRTNSRPLG
ADFRVHFGQI FNLQIVNWPE SLTLQVYETV GHSGTTLLAE VFLPIPETTV VTGRAPLEEV
EFSSNQHVTL DHEGVGSGVP FSFEADGSNQ LTLMTSGKVS NSVSWAIGEN GIPLIPPLSQ
QNIGFRSALK RADAISSIGT SGLTDMKKLA KWAAESKLDP NDPNNAPLMQ LILVATSGES
YVPDFFRLEQ LQQEFNFVSD EELNRSKRFR LLRLRSQEVP EFRNYKQIPV YDREIMEKVF
QDYEKRLRDR NVIETKDHID THRAIVAKYL QQVRESVINR FLIAKHHFLL ADLIVEEEVP
NISILGLRLF KLAEQKRPLR PRRKGRKKVT AQNLSDGDIK LLVNIIRAYD IPVRKPITSK
FQQPPRSSRT FSEKQAASPT THSPTHSADY PLSQVLVRPF VEVSFQRTIC HTTTADGPNP
SWNEELELPF RAPNGNYSTT SLQSVKDDVF INIFDEVLYD VLEDDRERAS GIHTRIERHW
LGCVKIPFST IYFQAKIDGT FKIDTPPVLL GYSKEQSVVA ERGFDPVRSL SEGSYITLFI
TMEPQLVPGE SVREKFDSQE DEKLLQATEK FQAECALKFP NRQCLTTVID ISGKTVFITR
YLKPLNPPQE LLNAYPNNPQ ATAELVARYV SLIPFLPDTV SFAGICDLWS TSDQFLDLLA
GDEEEHAVLL CNYFLSLGKK AWLMMGNAIP EGPTAYVLTR EQSHYLIWNP CSGHFYGQFD
TFCPLKSVGC LIGPDNIWFN IQRHDSPLRI NFDITKPKLW KSFFSRSLPY PGLSSVQPEE
LIYQRTDKAA AAELQDRIEK ILKEKIMDWR PRHLTRWNRY CTSTLRHFLP LLERSQGEDV
EDDHRAELLK QLGDYRFSGF PLHMPYSELK PLIEAVYSTG VHNIDVPNVE FALAVYIHPY
PKNVLSVWIY VASLIRNR
//
