ID F6Q681_ORNAN Unreviewed; 1294 AA.
AC F6Q681;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Tubulin--tyrosine ligase-like protein 5 {ECO:0000256|ARBA:ARBA00041448};
GN Name=TTLL5 {ECO:0000313|Ensembl:ENSOANP00000008043.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000008043.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000008043.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000008043.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000008043.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000008043.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-
CC glutamyl-L-glutamyl-[protein] + H(+) + phosphate;
CC Xref=Rhea:RHEA:60144, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143622,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036640};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60145;
CC Evidence={ECO:0000256|ARBA:ARBA00036640};
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DR Ensembl; ENSOANT00000008045.3; ENSOANP00000008043.3; ENSOANG00000005068.4.
DR GeneTree; ENSGT00940000162910; -.
DR Proteomes; UP000002279; Chromosome 1.
DR Bgee; ENSOANG00000005068; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF145; TUBULIN POLYGLUTAMYLASE TTLL5; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT REGION 409..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1294 AA; 144074 MW; 591013A02881BAB2 CRC64;
MPVVMARGLD EAAASSGEEE VAGPEDHQCI LWTGGCKRIP VLVFHAEAIL TKDSSIRVIG
ERYHLSYKIV RTDSRLVRSI LTAHGFHEVH PNSTEYNLMW TGSHLKPLLL RTLSDVQKVN
HFPRSYELTR KDRLYKNVIR MQQAHGFKAF HILPQTFLLP AEYPEFCSSY SKDRGPWIVK
PVASSRGRGV YLINNPNQIS LEENILVSRY INNPLLIDDF KFDVRLYVLV TSYDPLVIYL
YEEGLARFAT VRYDQGSKFI RNQFMHLTNY SVNKKSGDYV SCDDPEVEDY GNKWSMSAML
RYLKQEGRDT SVLMAHVEDL IIKTIISAEL AIATACKTFV PHRSSCFELY GFDVLIDATL
KPWLLEVNLS PSLACDSPLD LKVKASMISD MFTVVGFVCQ DPVQRSSRPA YPTYEASKRN
PFQKPQRPVT AQCRPTHSRL RSRPSSASDV ELKNLMVSGS EKIPGKLSGS VLGLSMEEIK
VLRRVKEENE RRGGFIRIFP TSETWGVYGS FLEYKTSMNY MLATRLFQDR GAPRGDLMAA
RVRMAVHGGA DVRLGYVNSK AKLHAALYER KLLSLEMRKH RQKRGKSKTL RSRYSAELHL
RSEPESEEEE ESIDNEDQEL KRTQDEAAGF LVESQVSLKP SVKMVLMGAL PQQNYLKESE
PQEPKAKINL LQVLQENGNL SKIQARKAFS VYLQRVQLRL MSETGFRRCS VMWAAKEDEQ
MELVVRFLKR AANNLQQSLK LSLPSRRLAI LERRRILGHQ LGEFIFHYSK ETEQMAEKRS
RKKSEEEEEE GINANHFQDF ITHASEKELE DVLTLYTQKN KSASIFLGTQ SKSNKPKSNY
SDSGAKGDDP ETMEEVKVKK PRPQAVGHPT PMDEEGKLPF GHSPCAAAAG PSAVFSRTHS
SQLSSRPLAP GCTLGPGVHP ALSHVPPTIA STVLPSSAAF QNPAPTSCCH SAFPEPPHAP
SPVGLPRCQS GSYSLGSVSS FPSTAQVFSQ RLSRPSSAKA GSCQRSPSRQ PAGSSKPQKE
GDDGSSQARW HNPSAFTSEY QRLVEKQAAR QYSPPSHISL LTQQLTNLNM ASGSIIRPGT
SSTPPTLRPS HNTGGSMWAI HSNAHVAENR CIPSGSRGLQ TDSSAWEGEL EMNAYSKVTG
VVPQHKYQPT AGSYQLHFAL QQLEQQKLQS RQPLDQSRAR HQLPSTSNVW AMPGSSSAHR
ASSATSSSQK AAILPPKVMA SQSCSSQLAP MPPSNHKQTA VRKISTQRIA KVTSTEGQLN
GFQNSLNHAG PYATLPNSTG FLRNPARPGI PYPT
//
