ID F6Q970_HORSE Unreviewed; 1041 AA.
AC F6Q970;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Platelet endothelial aggregation receptor 1 {ECO:0000313|Ensembl:ENSECAP00000018943.3};
GN Name=PEAR1 {ECO:0000313|Ensembl:ENSECAP00000018943.3,
GN ECO:0000313|VGNC:VGNC:21298};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018943.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018943.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018943.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018943.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018943.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; F6Q970; -.
DR Ensembl; ENSECAT00000022895.4; ENSECAP00000018943.3; ENSECAG00000021192.4.
DR VGNC; VGNC:21298; PEAR1.
DR GeneTree; ENSGT00940000154225; -.
DR TreeFam; TF332598; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000021192; Expressed in synovial membrane of synovial joint and 20 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 4.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24052; DELTA-RELATED; 1.
DR PANTHER; PTHR24052:SF12; PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1; 1.
DR Pfam; PF00053; Laminin_EGF; 4.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00180; EGF_Lam; 12.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1041
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040498052"
FT TRANSMEM 756..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..103
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 226..261
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 269..304
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 401..436
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 538..585
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 578..608
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 616..650
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 663..693
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 825..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 251..260
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 294..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 426..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 555..564
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 598..607
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 640..649
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 683..692
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1041 AA; 110444 MW; D704C11A878B95FD CRC64;
MSPPLHSLLL LALGLGLAGT LNPNDPNTCS FWESYTTTTK ESHTRPFSLL PSEPCDRPWE
SPHTCPRPTV VYRTVYRQVV KTDHRRRLQC CRGFYESSGA CVPLCAQECV HGRCVAPNQC
QCVQDWRGDD CSSACAPGMW GPQCDMPCSC GNSSSCDPKS GACSCPSGLQ PPHCLQPCSP
GRYGPACQFS CQCHGAPCDP HTGACFCPPE RTGPSSCEVS CHQGTVGFSC PSTHPCHNGG
VFQASQRSCS CPPGWMGTIC SLPCREGFHG PNCSQECRCH NGGLCDRFTG QCRCAPGYTG
DRCREECPVG RFGQDCAETC DCAPGARCFP ANGACLCEHG FTGDRCAERL CPDGLYGLSC
QVPCTCDPEH SLSCHPMSGE CSCLPGWAGL HCNESCPQDT HGPGCQEHCL CLHGGVCQPD
SGLCRCAPGY TGPHCASLCP PDTYGVNCSV RCSCENAIAC SPIDGTCVCK EGWQRGNCSV
PCLPGTWGFG CNASCQCAHE AACSPQTGAC TCTPGWHGVH CQLPCPKGQF GEGCASRCDC
DHSDGCDPVH GHCQCQAGWT GARCHLPCPA GFWGVNCSNT CTCKNGGTCI PENGNCVCAP
GFRGPSCQRP CQPGRYGKRC VPCKCANHSS CHPSDGTCYC LAGWTGPDCS QPCPLGHWGA
NCAQPCQCRH GGTCHPQDGS CFCPPGWTGH LCLEGCSPGT FGANCSQACQ CGSGERCHPE
TGACVCPPGH SGAPCRIGSQ ETFTIMPTSP VAYNSLGAVI GIAVLGSLVV ALVALFIGYR
HWQKGKEHQH LAVAYSSGRL DGSEYVMPDI PPSYSHYYSN PSYHTLSQCS PNPPPPNKVP
GGQLFASLQA PERPGGAHGH DNHATLPADW KHRREPPPGS LDRGSSCLDR SYSCSYSNSN
GPGPFYSKGP ISEEGLGASM ASLSSENPYA TIRDLPSLLG SPRESSYVEM KGPPSGSPPR
KLPQLRNSQR QRHTQPQRDS GTYEQPSPLT HDRDSVGSQP PLPPGLPPGH YDSPKNSHIP
GHYDLPPVRH PPSPPLRRQD R
//
