GenomeNet

Database: UniProt
Entry: F6Q9B1_XENTR
LinkDB: F6Q9B1_XENTR
Original site: F6Q9B1_XENTR 
ID   F6Q9B1_XENTR            Unreviewed;       468 AA.
AC   F6Q9B1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   20-JUN-2018, entry version 46.
DE   RecName: Full=Triacylglycerol lipase {ECO:0000256|RuleBase:RU362046};
DE            EC=3.1.1.3 {ECO:0000256|RuleBase:RU362046};
DE   AltName: Full=Pancreatic lipase {ECO:0000256|RuleBase:RU362046};
GN   Name=pnliprp2 {ECO:0000313|Ensembl:ENSXETP00000059545};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000059545, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000059545}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000059545}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a
CC       carboxylate. {ECO:0000256|RuleBase:RU362046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362046,
CC       ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU362046,
CC       ECO:0000256|SAAS:SAAS00591292}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAMC01128414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; F6Q9B1; -.
DR   Ensembl; ENSXETT00000062102; ENSXETP00000059545; ENSXETG00000032682.
DR   GeneTree; ENSGT00760000119069; -.
DR   InParanoid; F6Q9B1; -.
DR   OMA; PTMGHFA; -.
DR   OrthoDB; EOG091G0DJ5; -.
DR   TreeFam; TF324997; -.
DR   Reactome; R-XTR-192456; Digestion of dietary lipid.
DR   Reactome; R-XTR-975634; Retinoid metabolism and transport.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000032682; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR002331; Lipase_panc.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00823; PANCLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF49723; SSF49723; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Disulfide bond {ECO:0000256|RuleBase:RU362046,
KW   ECO:0000256|SAAS:SAAS00709807};
KW   Lipid degradation {ECO:0000256|RuleBase:RU362046};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU362046};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Secreted {ECO:0000256|RuleBase:RU362046,
KW   ECO:0000256|SAAS:SAAS00439306};
KW   Signal {ECO:0000256|RuleBase:RU362046}.
FT   SIGNAL        1     17       {ECO:0000256|RuleBase:RU362046}.
FT   CHAIN        18    468       Triacylglycerol lipase.
FT                                {ECO:0000256|RuleBase:RU362046}.
FT                                /FTId=PRO_5005129836.
FT   DOMAIN       20    350       Lipase. {ECO:0000259|Pfam:PF00151}.
FT   ACT_SITE    169    169       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    192    192       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    279    279       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
SQ   SEQUENCE   468 AA;  51128 MW;  A421CCB0962CE91C CRC64;
     MFYVLGLISF LLPSVQGLEE ICYEEVGCFP VGFPWAGTRE RPEGGLPWSP KMVNTRFLLF
     TRDNADHFQE INSSTISDSY FQTTRKTRFI IHGFIDVGTE GWVPDMCNAM LSVEDINCLS
     TDWSDGSHTD YVQAANNVRV VGAEVADLVK TLRDDLGYSP SLVHVIGHSL GAHAAGEAGK
     RMPGIGRITG LDPAQPYFQD TPEEVRLDPS DATLVDVIHT DSAPFIPSLG LGTGQLSGHL
     DFFPNGGIQM PGCKQKEEYN ISDIFIAFQG KHDDLVCNHL RSYRYYMESI TTPSGFTGFP
     AASYESFSSG AGFPCPANEC PVMGHYADLY SGATPSSQTY YLNTGDSPPF ARWRYKVTVH
     ISVPVSVLGS VWLSLLGLNG KTKMHDIYRG LINPNKHTGL FIDAETKVGP LVSAHFIWSS
     RNEAQAKSVT VEFGGDGTRY YSCGFRAASV GPGQIVPLCN RAAGPRDQ
//
DBGET integrated database retrieval system