ID F6QE14_HORSE Unreviewed; 853 AA.
AC F6QE14;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Sushi domain containing 2 {ECO:0000313|Ensembl:ENSECAP00000022647.3};
GN Name=SUSD2 {ECO:0000313|Ensembl:ENSECAP00000022647.3,
GN ECO:0000313|VGNC:VGNC:23772};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022647.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000022647.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022647.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000022647.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022647.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; F6QE14; -.
DR STRING; 9796.ENSECAP00000022647; -.
DR PaxDb; 9796-ENSECAP00000022647; -.
DR Ensembl; ENSECAT00000027072.3; ENSECAP00000022647.3; ENSECAG00000025078.3.
DR VGNC; VGNC:23772; SUSD2.
DR GeneTree; ENSGT00730000110943; -.
DR HOGENOM; CLU_019295_0_0_1; -.
DR InParanoid; F6QE14; -.
DR OMA; WLDHPTN; -.
DR OrthoDB; 5405959at2759; -.
DR TreeFam; TF321438; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000025078; Expressed in trophectoderm and 11 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IEA:Ensembl.
DR GO; GO:0051782; P:negative regulation of cell division; IEA:Ensembl.
DR CDD; cd00033; CCP; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR005533; AMOP_dom.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR13802; MUCIN 4-RELATED; 1.
DR PANTHER; PTHR13802:SF63; SUSHI DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF03782; AMOP; 1.
DR Pfam; PF00084; Sushi; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00723; AMOP; 1.
DR SMART; SM00032; CCP; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR PROSITE; PS50856; AMOP; 1.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
DR PROSITE; PS50923; SUSHI; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..853
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040376050"
FT TRANSMEM 817..839
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..66
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 316..464
FT /note="AMOP"
FT /evidence="ECO:0000259|PROSITE:PS50856"
FT DOMAIN 476..670
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 754..811
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 782..809
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 853 AA; 93563 MW; 83E19164C4B7C18A CRC64;
MKLLLLPWAL LLLVTAPSPG RWPAADAQES CSHRCGEWNE LCSCHPTCFG LDSCCKDFRD
FCLEILPYSG SMMGGKDFVV QHLNWFSPTD GVICRFNESV QTRGHVDSLG HVHCVSPLLY
ETGRIPFTLS MDNGSSFPRS GTWLAVHPSK VSQTEKLQLE NETRWQYYGT AGTKGNLTLT
WNTAALPTQS VTIELWGYEE TGCSEHQGLV PTSSSAPGVL GQAPGLTKDF IPSGKPYSED
WTAKWSYLYA LATNVSNSGF FTFTPEPAPQ NYQRWEVGAL RIINSEYHSG EKDVHALWSN
EHALAWHLGD DFRADPVAWA RTQCLAWEEL EDQLPNFLEE LPDCPCTLAQ ARSDSGRFHT
DYGCDIEHGS ECTYHPGAVH CVRSVQASPQ YASGQQCCYT AAGTQLLTAD SMGGSTPDRG
HDWGAPPFRA PPRVPGLSHW LYDVISFYHC CLWAPECSRY MRRRPSSDCR SYRPPRLASA
FGDPHFVTFD GANFTFNGHG EYVLLEASLT NLTVQARAQP DTTPEGTQAR GTGLTAVAVQ
EGDSDVVEVR LAGGAGVLQV LLNQEVLSFA EQSWMDLKGM FLSVAAEDRV SIMLSSGAGL
EVSIQGPFLS VTVLLPEKFL TYTQGLLGTL NDNFTDDFTL RSGQVLPPDA SSQELFQFGA
DWAVENASSL LTYDSQLLVN NFLYGPKHDP TFRPLFPDEI TPNSSQTTEV AKLCGDNHFC
SFDVAATGSL SVGNATRMAY QLHQRRVQSL QSVVSCGWLA PPLNGHKDGM RYLVGSTIHF
HCDTGYSLAG AEASTCQANG TWSTPTPTCQ PRRSHTVLLS IIFGGLAVVA LMAVVFVVLR
RRKGNMAIWG SQP
//
