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Database: UniProt
Entry: F6QGK3_MONDO
LinkDB: F6QGK3_MONDO
Original site: F6QGK3_MONDO 
ID   F6QGK3_MONDO            Unreviewed;      1640 AA.
AC   F6QGK3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   03-JUL-2019, entry version 60.
DE   SubName: Full=Roundabout guidance receptor 1 {ECO:0000313|Ensembl:ENSMODP00000021041};
GN   Name=ROBO1 {ECO:0000313|Ensembl:ENSMODP00000021041};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000021041, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000021041, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000021041}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   STRING; 13616.ENSMODP00000021041; -.
DR   Ensembl; ENSMODT00000021411; ENSMODP00000021041; ENSMODG00000016857.
DR   eggNOG; KOG4222; Eukaryota.
DR   eggNOG; ENOG410XPQS; LUCA.
DR   GeneTree; ENSGT00940000154477; -.
DR   InParanoid; F6QGK3; -.
DR   OMA; IGHMQHQ; -.
DR   TreeFam; TF351053; -.
DR   Proteomes; UP000002280; Chromosome 7.
DR   Bgee; ENSMODG00000016857; Expressed in 7 organ(s), highest expression level in testis.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0008046; F:axon guidance receptor activity; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0030275; F:LRR domain binding; IEA:Ensembl.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
DR   GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR   GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR   GO; GO:0021836; P:chemorepulsion involved in postnatal olfactory bulb interneuron migration; IEA:Ensembl.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR   GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0070100; P:negative regulation of chemokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0050925; P:negative regulation of negative chemotaxis; IEA:Ensembl.
DR   GO; GO:0050772; P:positive regulation of axonogenesis; IEA:Ensembl.
DR   GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
DR   GO; GO:1900748; P:positive regulation of vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR   GO; GO:0035385; P:Roundabout signaling pathway; IEA:Ensembl.
DR   CDD; cd00063; FN3; 3.
DR   Gene3D; 2.60.40.10; -; 8.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR032986; Robo1.
DR   PANTHER; PTHR12231:SF243; PTHR12231:SF243; 1.
DR   Pfam; PF00041; fn3; 3.
DR   Pfam; PF07679; I-set; 2.
DR   SMART; SM00060; FN3; 3.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 5.
DR   SMART; SM00406; IGv; 3.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712}.
FT   DOMAIN       60    156       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      162    249       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      254    338       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      343    438       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      447    533       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      555    649       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      668    765       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      770    866       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   REGION     1075   1101       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6QGK3}.
FT   REGION     1118   1328       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6QGK3}.
FT   REGION     1343   1388       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6QGK3}.
FT   REGION     1412   1640       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6QGK3}.
FT   COMPBIAS   1118   1158       Polar. {ECO:0000256|MobiDB-lite:F6QGK3}.
FT   COMPBIAS   1242   1262       Polar. {ECO:0000256|MobiDB-lite:F6QGK3}.
FT   COMPBIAS   1348   1388       Polar. {ECO:0000256|MobiDB-lite:F6QGK3}.
FT   COMPBIAS   1430   1444       Polar. {ECO:0000256|MobiDB-lite:F6QGK3}.
FT   COMPBIAS   1504   1530       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                F6QGK3}.
FT   COMPBIAS   1545   1568       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                F6QGK3}.
FT   COMPBIAS   1581   1610       Polar. {ECO:0000256|MobiDB-lite:F6QGK3}.
SQ   SEQUENCE   1640 AA;  179327 MW;  42909D406A1512A2 CRC64;
     MCVCASVADP QIWGRVTPSW NETACRRHAR TMIAESAHFY LFGLICLCSG SRLRQEDFPP
     RIVEHPSDLI VSKGEPATLN CKAEGRPTPT IEWYKGGERV ETDKDDSRSH RMLLPSGSLF
     FLRIVHGRKS RPDEGVYICV ARNYLGEAVS HNASLEVAIL RDDFRQNPSD VMVAVGEPAV
     MECQPPRGHP EPTISWRKDG SPLDDRDERI TIRGGKLMIT YTRKSDAGKY VCVGTNMVGE
     RESEVAELTV LERPSFVKRP SNLAVTVEDS AEFKCEARGD PVPTVRWRKD DGELPKSRYE
     IRDDHTLKIR KVMAGDMGSY TCVAENMVGK AEASATLTVQ EPPHFVVKPR DQVAALGRTV
     TFQCEATGNP QPAIFWRREG SQNLLFSYHP PQSSSRFSVS QTGDLTITNV QRSDVGYYIC
     QTLNVAGSII TKAYLEVTDV IADRPPPVIQ QGPGNQTVAV DGTLVLSCVA TGSPVPTILW
     RKDGVLVPTQ DSRIKQLDTG ALQIRYAKLG DTGRYTCIAS TPSGEATWSA YIEVQEFGIP
     VQPPRPTDPN LIPSAPSKPE VTDVSRNTVT LSWQPNLNSG ATPTSYIIEA FSHASGSSWQ
     TVAENVKTET FATKGLKPNA IYLFLVRAAN AYGLSDPSQI SDPVKTQDVP PTSQGVDHKQ
     VQRELGNVVL HLHNPTVLSS SSIEVHWTVD QQSQYIQGYK ILYRPSSAPH GDSEWLVFEV
     RTPTQNSAIL PELRKGASYE IKARPFFNEF QGADSDVKLA KTLEEAPSAP PQSVTISKND
     GNGTAILVTW QPPPEDTQNG MVQEYKVWCL GNESRYHINK TVDGSTFSVI IPSLVPGVRY
     SVEVAASTGA GSGVKSEPQF IQLDSHGNPV SPEDQVSLAQ QISDVVKQPA FIAGIGAACW
     IILMVFSIWL YRHRKKRNGL TSTYAGIRKV PSFTFTPTVT YQRGGEAVSS GGRPGLLNIN
     EPAAQPWLAD TWPNTGSSHN DCSINCCTAS NGNSDGNLTT YSRPADCIAN YNNQLDNKQS
     NLMLPEPTVY GDVDLSNKIN EMKTFNSPNL KDGRLVTAPG QPTPYATTQL IQSGISNNIN
     NGHGEASEKP WKASSQPKQE AASIQYNIME QNKLNKDYRT TDTIPPTIPY NQSYDQNTGG
     SYNSSDRGSS TSGSQGHKKG ARTPKLPKQT GMNWADLLPP PPAHPPPHSH SEDYSLSVDE
     SYDQEIPCPV PPARMYLQQE ELEEEDERGP TPPVRGAASS PAAVSYSHQS TATLTPSPQE
     ELQPMLQDCP EDIGHGQHHP DRRRQPVSPP PPPRPISPPH TYGYISGPLV SDMDTDVPEE
     EEDEADMEVA KMQTRRLLLR GLEQTPASSV GDLESSVTGS MINGWGSASE EDNISSGRSS
     VSSSDGSFFT DADFAQAVAA AAEYAGLKVA RRQMQDATGR RHFHGSHCPR PTSPVSTDSN
     VSAALMQRAR PAKKQKHAPG HPRREVYTDD LPPPPVPPPA LKSPTVQSKG HLEGRPMMLP
     KLPHVEARAD RSAERKGGGY KGREALDGRP ASDTRTNPGE PRDAQELQGD GKARGNKASR
     RDLPPPKTHL VQEDILPYCR PTFPTSNNPR DPSSSSSMSS RGSGRQRDQA NIGRRNVAEM
     QVLGAYEKEV DNEELEETES
//
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