ID F6QH06_HORSE Unreviewed; 1524 AA.
AC F6QH06;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Shroom family member 2 {ECO:0000313|Ensembl:ENSECAP00000010029.4};
GN Name=SHROOM2 {ECO:0000313|Ensembl:ENSECAP00000010029.4,
GN ECO:0000313|VGNC:VGNC:55534};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010029.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010029.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010029.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010029.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010029.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the shroom family.
CC {ECO:0000256|ARBA:ARBA00006469}.
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DR Ensembl; ENSECAT00000012697.4; ENSECAP00000010029.4; ENSECAG00000012150.4.
DR VGNC; VGNC:55534; SHROOM2.
DR GeneTree; ENSGT00940000155212; -.
DR HOGENOM; CLU_003220_0_0_1; -.
DR Proteomes; UP000002281; Chromosome X.
DR Bgee; ENSECAG00000012150; Expressed in prefrontal cortex and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.250.3120; -; 1.
DR InterPro; IPR014800; ASD1_dom.
DR InterPro; IPR014799; ASD2_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR027685; Shroom_fam.
DR PANTHER; PTHR15012; APICAL PROTEIN/SHROOM-RELATED; 1.
DR PANTHER; PTHR15012:SF8; PROTEIN SHROOM2; 1.
DR Pfam; PF08688; ASD1; 1.
DR Pfam; PF08687; ASD2; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51306; ASD1; 1.
DR PROSITE; PS51307; ASD2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00637};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 13..68
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 631..719
FT /note="ASD1"
FT /evidence="ECO:0000259|PROSITE:PS51306"
FT DOMAIN 1225..1519
FT /note="ASD2"
FT /evidence="ECO:0000259|PROSITE:PS51307"
FT REGION 157..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1272..1296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1313..1369
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 274..288
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..782
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..923
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..981
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1524 AA; 166992 MW; D082D7DF52D2CC44 CRC64;
MITCLSAEDF PELEQIEEGS KAAAVDKLLA GDEIVGINDI GLSGFRQEAI CLVKGSHKTL
KLVVKRRNEL SWRPHSWHAT KFSESHPETS ASQFSTSVYP SWHGRHHASS SSHDLSGTWE
QTNLQRTSDH FSSLGSVDSL DHPCQPYSSG CLSAAKSNSS IDRLGGPNQR DSAYGSFSTS
SSTPDHTLPK ADASSTENIL YKVGLWEASK PGSSRQGQAA GDPQGLEDRL GYFPPRVLCD
SSKSPRPDDS PEPKVASSGR SSFGPVWYVP DKKKAPSSPP PPPPPLRSDS FAATKSHEKA
QGPPFSEVAD TQHFPGLTWA QPRSDWRPEP GDQQRRLAHP TDGRRPGGSV WAPDAPCEWP
ASDHEAPSML QASLSSTDVR CPQPSYGYQH LRQYSDESPF LYEGPSATTS PRKQLHVALT
GGFQDDSPTQ VRWPSAADQK GDSSGQSRFC APMRQCLQGG TRAAPLRGAG WHPATQPPGP
KPRGGLSLLE GSRGAPVRAS GDPEGRSPGV MERAGLKKAM TGLPWADGES SKISPRQTPM
LHLLAQEGTR RPEDSQEGDP ERPPPLDAQG GKPTRRSDRF ATTLRNEIQM RRAKLQKSKS
TVTLAGTSEG EEEAAGAGPE GSFPGTYKDH LQEAQARVLR ATSFKRRDLD PSPADHYTGL
PDHSTDPDPV PRSWEVSLAK PPSSAGGMPH VPRIGGRRRF TVEQKLKSYS EPEKMHEVGL
SGDHRPPQHP GTSQETMGTF ADRWKFFEET SRPVQQRPGQ RQALCGLSKE KLERPRTGGH
VCEDAEPCFQ KRAHTTSFGE NADGHRTAGK LGKSEPPQRL GTFAEYQASW REQRNALEAR
SSGRYHSADD ILDAGLDQHE RPQYIHERSR SSPSTDLYKQ EASVEPRRQA EDPGEHKELS
PTVRAEEGRL TPRQADAQCR EDSPGDQRNL SQVSELPHVP GAPEAPCEGR GRAGTLPRDY
RYSEDKAPAT PPPPLGPGPT APAQALRPVS ARRPGPQRPL RGPTGPAAGP RSRPRPLASP
VALEVCVARL SLSCSPSASA EEPSSAQPAD GPKAAAEHDR QDVDERAACP FPSQCRPLPP
AAMDTSRSPS PQFAPQKLTD KPPLLIQDEN STRIERVIDN NTTVKMVPIK IVHSESQPEK
ESRQGLARAT ELPELPSGLE RDQIKTLSTS EQCYSRFCVY SRQGPEAEPQ PPGALAPAAK
DSQASPPGLS YVKAKERTAE DLKSEELARE IVGKDKSLAD ILDPGVKIKT AMDLMEGIFP
KDEHLLEEAQ QRRKLLPKIP SPRTAEEKKE EPSVPAAVSL ATSSTYYSTS APKAELLIKM
KDLREQQESE ESSGSDLDHD LSVKKQELIE SISRKLHVLR EARESLLEDI QANSVLGDEV
EAIAKDVCKP NEFDKFRMFI GDLDKVVNLL LSLSGRLARV ENALNNLDDS TSPGDRQSLL
EKQRVLIQQH EDAKELKENL DRRERIVFDI LASYLSEESL ADYEHFVKMK SALIIEQREL
EDKIHLGEEQ LKCLFDSLQP ERGK
//
