ID F6QHI9_HORSE Unreviewed; 1065 AA.
AC F6QHI9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=SLIT-ROBO Rho GTPase activating protein 1 {ECO:0000313|Ensembl:ENSECAP00000010007.3};
GN Name=SRGAP1 {ECO:0000313|Ensembl:ENSECAP00000010007.3,
GN ECO:0000313|VGNC:VGNC:23581};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010007.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010007.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010007.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010007.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010007.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6QHI9; -.
DR Ensembl; ENSECAT00000012670.3; ENSECAP00000010007.3; ENSECAG00000011462.3.
DR VGNC; VGNC:23581; SRGAP1.
DR GeneTree; ENSGT00950000182824; -.
DR HOGENOM; CLU_005715_0_0_1; -.
DR TreeFam; TF315892; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000011462; Expressed in trophectoderm and 20 other cell types or tissues.
DR ExpressionAtlas; F6QHI9; baseline.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07683; F-BAR_srGAP1; 1.
DR CDD; cd04383; RhoGAP_srGAP; 1.
DR CDD; cd11955; SH3_srGAP1-3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035648; srGAP1/2/3_SH3.
DR InterPro; IPR037451; srGAP1_F-BAR.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR14166:SF15; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 2..294
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 486..674
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 723..782
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 455..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 332..359
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 788..810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1054
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 121771 MW; F69EC20EE5C2D0E6 CRC64;
MLEIRAQLVE QQKCLEQQTE MRVQLLQDLQ DFFRKKAEIE TEYSRNLEKL AERFMAKTRS
TKDHQQYKKD QNLLSPVNCW YLLLNQVRRE SKDHATLSDI YLNNVIMRFM QISEDSTRMF
KKSKEIAFQL HEDLMKVLNE LYTVMKTYHM YHAESISAES KLKEAEKQEE KQIGRSGDPV
FHIRLEERHQ RRSSVKKIEK MKEKRQAKYS ENKLKSIKAR NEYLLTLEAT NASVFKYYIH
DLSDLIDCCD LGYHASLNRA LRTYLSAEYN LETSRHEGLD IIENAVDNLE PRSDKQRFME
MYPAAFCPPV KFEFQSHMGD EVCQVSAQQP VQAELMLRYQ QLQSRLATLK IENEEVKKTT
EATLQTIQDM VTIEDYDVSE CFQHSRSTES VKSTVSETYL SKPSIAKRRA NQQETEQFYF
MKLREYLEGS NLITKLQAKH DLLQRTLGEG HRAEYMTTRP PNVPPKPQKH RKSRPRSQYN
AKLFNGDLET FVKDSGQIIP LIVESCIRFI NLYGLQHQGI FRVSGSQVEV NDIKNSFERG
ENPLADDQNN HDINSVAGVL KLYFRGLENP LFPKERFNDL ISCIRTDNLY ERALHIRKLL
LTLPRSVLIV MRYLFAFLNH LSQYSDENMM DPYNLAICFG PTLMPVPEIQ DQVSCQAHVN
EIVKTIIIHH ETIFPDAKEL DGPVYEKCMA GDDYCDSPYS EHGTLEEVDQ DAGTEPHTSE
DECEPIEAIA KFDYVGRSAR ELSFKKGASL LLYHRASEDW WEGRHNGIDG LVPHQYIVVQ
DMDDTFSDTL SQKADSEASS GPVTEDKSSS KDMNSPTDRH PDGCLARQRK RGEPPPPVRR
PGRTSDGHCP LHPPNALSNS SVDLGSPNLA SHPRGLLQNR GLNNDSPERR RRPGHGSLTN
ISRHDSLKKI DSPPIRRSTS SGQYTGFNDH KPLDPETIAQ DIEETMNTAL NELRELERQS
TAKHAPDVVL DTLEQVKNSP TPATSTESLS PLHSVALRSS EPQIRRSTSS SSDTMSTFKP
MVAPRMGVQL KPPALRPKPA VLPKTNPTIG PAPPSQGPTD KSCTM
//
