ID F6QHP9_HORSE Unreviewed; 720 AA.
AC F6QHP9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=NCK interacting protein with SH3 domain {ECO:0000313|Ensembl:ENSECAP00000010004.3};
GN Name=NCKIPSD {ECO:0000313|Ensembl:ENSECAP00000010004.3,
GN ECO:0000313|VGNC:VGNC:56835};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010004.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010004.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010004.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010004.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010004.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6QHP9; -.
DR STRING; 9796.ENSECAP00000010004; -.
DR PaxDb; 9796-ENSECAP00000010004; -.
DR Ensembl; ENSECAT00000012666.3; ENSECAP00000010004.3; ENSECAG00000012037.4.
DR VGNC; VGNC:56835; NCKIPSD.
DR GeneTree; ENSGT00390000015725; -.
DR HOGENOM; CLU_012978_1_0_1; -.
DR InParanoid; F6QHP9; -.
DR OMA; TGFERQY; -.
DR TreeFam; TF324522; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000012037; Expressed in prefrontal cortex and 23 other cell types or tissues.
DR GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
DR GO; GO:0071933; F:Arp2/3 complex binding; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR CDD; cd11849; SH3_SPIN90; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR030125; SPIN90/Ldb17.
DR InterPro; IPR018556; SPIN90/Ldb17_LRD.
DR InterPro; IPR035514; SPIN90_SH3.
DR PANTHER; PTHR13357:SF1; NCK-INTERACTING PROTEIN WITH SH3 DOMAIN; 1.
DR PANTHER; PTHR13357; SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF09431; SPIN90_LRD; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..58
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 101..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 78942 MW; 4A8E538D004BFAF6 CRC64;
MYRALYAFRS AEPNALAFAA GETFLVLERS SAHWWLAARA RSGETGYVPP AYLRRLQGLE
QDVLQAIDRA IEAVHNAAMR NGGKYSLEQR GVLQKLIHHR KETLSRRGPS ASSPSAMTPS
TSDHHLDAAA ARQPNGVCRA GFERQHSLPS SEYLGVDGGL YQIPPQPRRA APATPPPPVK
RRDRDTLVAS GSGGRNTTPS GGSSVSSGSS VSSTSLDMLC TGSSSSEPGP SCSPTPPPVP
RRGTHTTVSQ AQPPPSKVPA PKPPTEEVAV DTTSAPDKLE ALSALSLGTT EEKAVAETAV
PRTIGAELME LVRRNTGLSH ELCRVAIGVV VGHIQASVPA ISHVMEQVLL SLVEGKDLST
ALPSGQVCHD QQRLEVIFAD LARRKDDAQQ RSWALYEDEG VIRCYLEELL HILTDADPEV
CKKMCKRNEF ESVLALVAYY QMEHRVSLRL LLLKCFGAMC SLDAAIISTL LSSVLPVELA
RDMQTDTQDH QKLCYSALIL AMVFSMGEAV PYAHYEHLGT PFAQFLLSIV EDGLPLDTTE
QLPDLCMNLL LALNLHLAAP DQNVIMAALS KHANVKVFSE KLLLLLNRGD DPVRIFKHEP
QPPHSILKFL QDVFASPATA AIFYHTDMMA LIDITVRHIA DLSPGDKTRY MCQLRMEYLS
LMHAVVRSTP YLQHRHRLPD LQATLRRILT EEEASPQCQM DRMIVREMCK EFPVLGETPS
//
