ID F6QIU1_MONDO Unreviewed; 3288 AA.
AC F6QIU1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=CUB and Sushi multiple domains 1 {ECO:0000313|Ensembl:ENSMODP00000017639.3};
GN Name=CSMD1 {ECO:0000313|Ensembl:ENSMODP00000017639.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000017639.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000017639.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000017639.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR STRING; 13616.ENSMODP00000017639; -.
DR Ensembl; ENSMODT00000017967.3; ENSMODP00000017639.3; ENSMODG00000014053.4.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000155701; -.
DR HOGENOM; CLU_000277_0_0_1; -.
DR InParanoid; F6QIU1; -.
DR OMA; DLVNFTC; -.
DR TreeFam; TF316872; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000014053; Expressed in spinal cord and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:1990708; P:conditioned place preference; IEA:Ensembl.
DR GO; GO:0008585; P:female gonad development; IEA:Ensembl.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0060745; P:mammary gland branching involved in pregnancy; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0035846; P:oviduct epithelium development; IEA:Ensembl.
DR GO; GO:0001964; P:startle response; IEA:Ensembl.
DR CDD; cd00033; CCP; 27.
DR CDD; cd00041; CUB; 12.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 27.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 12.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF15; -; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 12.
DR Pfam; PF00084; Sushi; 27.
DR SMART; SM00032; CCP; 27.
DR SMART; SM00042; CUB; 12.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 27.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 12.
DR PROSITE; PS01180; CUB; 12.
DR PROSITE; PS50923; SUSHI; 27.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3212..3233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..132
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 135..246
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 249..306
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 308..416
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 419..480
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 482..590
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 595..652
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 654..764
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 767..826
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 828..936
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 939..999
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1001..1110
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1113..1173
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1175..1283
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1286..1347
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1349..1457
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1463..1524
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1526..1634
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1637..1696
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1698..1806
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1809..1868
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1870..1981
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1980..2041
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2043..2154
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2154..2216
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2217..2278
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2279..2343
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2344..2401
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2402..2459
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2460..2517
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2518..2580
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2581..2638
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2642..2699
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2700..2758
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2759..2818
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2819..2876
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2877..2934
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2938..2996
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2997..3056
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 277..304
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 623..650
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1001..1028
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2372..2399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2430..2457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2488..2515
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2551..2578
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2609..2636
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2670..2697
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2729..2756
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2847..2874
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2905..2932
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2967..2994
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3288 AA; 360192 MW; 8F6364A2D8F77496 CRC64;
MNLPSPVISS KNWLRLHFTS DSNHRRKGFN AQFQVKKAIE LKSRGVKMLP NKDNNHKNSV
LTQGGVALVS DMCPDPGIPE NGRRTGSDFR VGANVQFSCE DNYVLQGSKS ITCQRVTETL
AAWSDHRPIC RARTCGSNLR GPSGIITSPN YPVQYEDNAH CVWVITTTDP EKVIKLAFEE
FELERGYDTL TVGDAGKVGD TRTVLYVLTG SSVPDLIVSM SNQMWLHLQS DDSIGSPGFK
AVYQEIDKGG CGDPGIPSYG KRTGNSFLHG DTLTFECQAA FELVGERVIT CQQNNQWSGN
KPSCVFSCFF NFTTPSGIIL SPNYPEEYGN NMNCVWLIIS EPGSRIHLIF NDFDVEPQFD
FLAVKDDGMS DVSVLGTFSG NEVPSQLASS GHIVRLEFQS DHSTTGRGFN ITYTTFGQNE
CHDPGIPING RRFGDRFLLG SSVSFHCDDG FVKTQGSESI TCIMQDGNVV WSSTVPRCEA
PCGGHLTASS GVILPPGWPG YYKDSLNCEW VIEAKPGHSI KITFDRFQTE VNYDTLEVRD
GPANSSPLIG EYHGTQAPQF LISTGNYMYL LFTTDNSRSS VGFLIHYESV TLESDSCLDP
GIPVNGHRHG NNFGIRSTVT FNCDPGYTLS DEEPLVCERN HQWNHALPSC DALCGGYIHG
KSGTVLSPGF PDFYPNSLNC TWTIEVSHGK GVQMIFHTFH LESSHDYLLI TEDGSFTEPV
ARLTGSVLPH TIKAGLFGNF TAQLRFISDF SISYEGFNIT FSEYDLEPCD DPGVPAFSRR
IGFHFGVGDS LTFSCFPGYR LEGATKLTCL GGGRRVWSAP LPRCVAECGA SVTGNEGTLL
SPNFPSNYDN NHECIYKIET EAGKGIHLRA RSFQLHEGDV LKVFDGKNSA SRPLGAFSKN
ELMGLILNST SNHLWMEFNT NGSNTDQGFQ LTYTSFDLVK CEDPGIPNYG YKIRDEGHFT
DTIVQYSCNP GYAMHGSSTM TCLSGDRRVW DKSLPSCIAE CGGRIHAATS GRILSPGYPA
PYDNNLHCTW IIEADPGKTI SLHFIVFDTE MAHDILKVWD GPIDSNIFLK EWSGSALPED
IHSTFNSLTL QFDSDFFISK SGFSIQFSTS IASTCNDPGM PQNGTRYGDS REPGDTITFQ
CDPGYQLQGQ AKITCVQLNN RFFWQPDPPT CIAACGGNLT GPAGVILSPN YPQPYPPGKE
CDWRIKVNPD FVIALIFKSF NMEPSYDFLH IYEGEDSNSP LIGSFQGSQA PERIESSGNS
LFLAFRSDAS VGLSGFAIEF KEKPREACFD PGNIMNGTRI GTDFKLGSTV TYQCDSGYKI
IDPSSITCEI GVDGKPAWNR ILPSCNAPCG GQYTGSEGVV LSPNYPHNYT AGQMCHYSIT
VPKEFVVFGQ FAYFQTALND LAELFDGAHP QARLLSSLSG FHSGETLPLA TSNQILLRFS
AKSGASARGF HFVYQAVPRT SDTQCSSVPE PRYGRRIGSE FSAGSIVRFE CNPGYLLQGS
KAIRCQSVPN ALAQWNDTIP SCVVPCSGNF TQRRGTILSP GYPEPYGNNL NCIWKIIVTE
GSGIQIQVIS FATEQNWDSL EIYDGADMTA PRLGSFSGTT VPALLNSTSN QLYLHFQSDI
SVAAAGFHLE YKTVGLAACQ EPVLPSNGIK IGDRYMVNDV LYFQCEPGYT LQGRSHISCM
PGTVRRWNYP SPLCIAKCGG TLNSMTGVIL SPGFPGAYPN NLDCTWKISL PIGYGAHIQF
MNFSTEANHD YLEIQNGPFH TSPMIGQFSG TDIPSALLST THETLIHFYS DHSQNRQGFK
LAYQAYELQN CPDPPPFQNG YMVNSDYSVG QSISFECYPG YVLIGHPVLT CQHGINRNWN
YPFPRCDAPC GYNVTSQNGT VYSPGFPDEY PILKDCIWLI TVPQGHGVYI NFTLLQTEAV
NDYIAVWDGP DQNSPQLGIF SGNTALETAY SSTNQVLLKF HSDFSNGGFF VLNFHAYQLK
KCQSPPAVPQ AEILTEDNDF EIGDFVKYQC LPGYTLSGTD ILTCKLSAQL QFEGSPPTCE
AQCPANEVRT ESSGVILSPG YPGNYFNSQT CSWTIKVEVG YNITVFVETF QSEKQFDVLE
IFDGSSGQSP LLVLLSGNHT EQSNYTSKSH QLYFRWSTDH ATSKKGFKIR YSAPYCSLTQ
TLKNGGIVNR TRGPVGSRVH YFCKPGHRMI GHSNATCRRN PNGLYQWDSL TPLCQAVSCG
IPESPGNGSF MGNEFTLDSK VNYECNEGFR LESSQQGTAT CQEDGLWSNK GKPPTCKPMT
CPSIETQLSE HVIWRLVSGS VNEYGAQVVL SCSPGFYLDG QRLIQCQANG TWSIRDERPS
CKVISCGGLS FPPNGNKIGT LTIYGATAIF TCNTGYTLVG SHVRECLANG LWSGMETRCL
AGHCGSPDPI VNGHISGDGF SYRDTVVYQC NPGFRLVGTS VRICLQDHKW SGQTPVCVPI
TCGHPGNPAH GLTNGSEFNL NDVVNFTCST GYLLQGAARA QCRSNGQWSS PLPTCRVVNC
SDPGFVENAI RHGQQNYLES FKYGISVMYH CKKGFYLLGS SALTCKANGL WDRSLPKCLP
ISCGHPGIPA NAILTGEQFT YGSIIHYSCT VSRTLMGNAT RICQEDSHWS GTLPHCSGNS
PGFCDDPGTP AHGSRLGEEF KVKSLLRFSC EMGYQLRGSP ERTCLFNGSW SGVQPVCEAV
SCGNPGTPAN GMIINSDGIL FSSSVIYACW EGYKTSGLTT RHCTANGTWT GTAPDCTVIS
CGDPGTLANG IQFGNDFTFN KTVSYQCNPG YLMEPASAST IQCTKESTWN QSKPVCKAVM
CGQPPQVQYG KVEGTDYHWG ASISYSCAEG YQLSNSAILS CEGRGVWRGD VPQCLPVFCG
DPGTPAEGRI SGKSFIYRSE VSFQCKSPFI LIGSSRRLCQ ADGTWSGIQP TCIDPAHNTC
TDPGTPHFGM QNSSRGYEVG STVFFRCRKG YHIQGSTTRS CLANLTWSGI QTECIPHACR
QPETPAHADV RAIDLPTFGY TLVYTCHPGF FLAGGSEHRT CKPDMKWTGK SPVCKSKGVR
EVNETVTKTP VPSDVFFINS VWKGYYEYLG KRHPATLTVD WFNATSSKVN ATFIEGSNME
LKLSGVYKKE EAHLLLKVFQ IKGPVDIFVS KFENDNWGLD GYVSSGLERG GFTFQGDIHG
KDFGKFKLER QGPLSIDPDS SNHYYGTNSS SVAAAILVPF FALILSGFAF YLYKHRTRPK
VQYNGYAGHE NSNGQASFEN PMYDTNLKPT EAKAVRFDTT LNTVCTVV
//