ID   F6QJK1_CALJA            Unreviewed;       866 AA.
AC   F6QJK1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 3.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=Dimethylglycine dehydrogenase {ECO:0000313|Ensembl:ENSCJAP00000036779.3};
GN   Name=DMGDH {ECO:0000313|Ensembl:ENSCJAP00000036779.3};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000036779.3, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000036779.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000036779.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
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DR   AlphaFoldDB; F6QJK1; -.
DR   STRING; 9483.ENSCJAP00000036779; -.
DR   Ensembl; ENSCJAT00000038842.3; ENSCJAP00000036779.3; ENSCJAG00000019768.6.
DR   eggNOG; KOG2844; Eukaryota.
DR   GeneTree; ENSGT00940000158176; -.
DR   HOGENOM; CLU_007884_11_1_1; -.
DR   InParanoid; F6QJK1; -.
DR   OrthoDB; 1815533at2759; -.
DR   TreeFam; TF314735; -.
DR   Proteomes; UP000008225; Chromosome 2.
DR   Bgee; ENSCJAG00000019768; Expressed in liver and 3 other cell types or tissues.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT   DOMAIN          52..414
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          417..470
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          479..744
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          770..847
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
FT   REGION          19..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   866 AA;  97194 MW;  4444C53E3F4D84B2 CRC64;
     MLRPGAQRLR GILLRSCRRR GSPGRPRSVC GQEGEEKPPS SAETQWKDRA ETVIIGGGCV
     GVSLAYHLAK AGMKDVVLLE KSELTAGSTW HAAGLTTYFH PGINLKKIHY DSIKLYEKLE
     EETGQVVGFH QPGSIRLATT PVRVDEFKYQ MTRTGWHATE QCIIEPEKIQ EMFPLLNMNK
     VLAGLYNPGD GHIDPYSLTM ALAAGARKYG ALLKYPAPVT SLKPRSDGTW DVETPQGSMR
     ANRIVNAAGF WAREVGKIIG LEHPLIPVQH QYVVTSTIPE VKALKRELPV LRDLEGSYYL
     RQERDGLLFG PYESQEKMKV QDSWVTNGVP PGFGKELFES DLDRIMEYIE IAMEMVPVLK
     NADIINVVNG PITYSSDILP MVGPHQGVRN YWVAIGFGYG IIHAGGVGKY LSDWILHGEP
     PFDLIELDPN RYGKWTTTQY TEAKARESYG FNNIVGYPKE ERFAGRPTQR VSGLYRSLES
     KCSMGFHAGW EQPHWFYKPG QDTQYRPSFR RTNWFEPVGS EYKQVMQRVG VIDLTPFGKF
     NIKGRDSIRL LDRLFANIIP KVGFTNISHM LTPKGRVYAE LTVSHQCPGE FLLITGSGSE
     LHDLRWIEEE AVKGGYDVEI KNITDEFGVL GVAGPRARKI LQKLTSEDLS EDVFKFLQTK
     SLKISNIPVT AIRISYTGEL GWELYHRRED SVALYDMIMN AGQEEGIDNF GTYAMNALRL
     EKAFRAWGSE MNCDTNPLEA GLEYFVKLNK PADFIGKQAL KQIKAKGLKR RLVCLTLATD
     DVDPEGNESI WYNGKVVGNT TSGSYSYSIQ KSLAFAYVPI ELSEVGQQVE VELLGKNYPA
     VIIQEPLVLT EPTRNRLQKK GGKDKT
//