ID F6QML3_XENTR Unreviewed; 793 AA.
AC F6QML3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Adducin 1 {ECO:0000313|Ensembl:ENSXETP00000054665};
DE SubName: Full=Alpha-adducin isoform X8 {ECO:0000313|RefSeq:XP_017947481.1};
GN Name=add1 {ECO:0000313|Ensembl:ENSXETP00000054665,
GN ECO:0000313|RefSeq:XP_017947481.1,
GN ECO:0000313|Xenbase:XB-GENE-995030};
GN Synonyms=add2 {ECO:0000313|RefSeq:XP_017947481.1}, adda
GN {ECO:0000313|RefSeq:XP_017947481.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000054665};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000054665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000054665};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000054665}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_017947481.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_017947481.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_017947481.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
CC -!- SIMILARITY: Belongs to the aldolase class II family. Adducin subfamily.
CC {ECO:0000256|ARBA:ARBA00006274}.
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DR RefSeq; XP_017947481.1; XM_018091992.2.
DR Ensembl; ENSXETT00000054665; ENSXETP00000054665; ENSXETG00000008015.
DR GeneID; 448173; -.
DR AGR; Xenbase:XB-GENE-995030; -.
DR CTD; 118; -.
DR Xenbase; XB-GENE-995030; add1.
DR eggNOG; KOG3699; Eukaryota.
DR TreeFam; TF313003; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000008015; Expressed in brain and 16 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.225.10; Class II aldolase/adducin N-terminal domain; 1.
DR InterPro; IPR001303; Aldolase_II/adducin_N.
DR InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR PANTHER; PTHR10672; ADDUCIN; 1.
DR PANTHER; PTHR10672:SF4; ALPHA-ADDUCIN; 1.
DR Pfam; PF00596; Aldolase_II; 1.
DR SMART; SM01007; Aldolase_II; 1.
DR SUPFAM; SSF53639; AraD/HMP-PK domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 147..329
FT /note="Class II aldolase/adducin N-terminal"
FT /evidence="ECO:0000259|SMART:SM01007"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 793 AA; 87061 MW; 1DB96778D8F2422B CRC64;
MNGDSNAGVV TTPPPTNPPH KEKYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM
ILQSPAFCDE LESLIQDQLK KGKNPTGLLA LQQIADFMTT GVPNVYPSAP QGGMAALNLS
LGMVTPVNDL RGSDSIAYEK GEKLLRCKLA AFHRLADLFG WSQLIYNHIT VRVNSEQEHF
LIVPFGLLYS EVTASSLIKV NLQGELVDRG STNLGVNKAG FTLHSAIYAA RPDVKCIVHI
HSPAGAAVSA MKCGLLPLSP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR
NHGLVTMGET VEEAFYYIHN LMSACEIQVR TLASAGGPDN LVLLDPGKYK KSRSPETPSG
DGSGLHPKWL VGEQEFEALM RMLDNLGYRT GYPYRCPALR EKAKKYSDVE IPASVTGYSL
GNDGGSGTCS PLRHSFQKQQ REKTKWLNSG RADDTSEDGQ NGGSPKSKTK VWTNITHDHV
KPLLQSLSSG VCVPSCITNC LWTKEDGMKS ATSAVPNMFV PLNTDPKEVQ EMRNKIREQN
LQDIKTAGPQ SQVLCGVVVD RSVVQRLAVY KDAPLSDCSE TIEGLDLTEQ TFSPAKTLSV
RKGELVTASK AIIEKEYQPK VIVTSTGPNP FNKFSDRELE EYHKEIERKQ KGAEDCGETA
VSPSSLEGVV LSTHGPNGEP VSSQSEAERN EQIHTSLAEV NGEEPRAAPE HHHSELPVTG
VLIAEENGLS PHKEFHTAVI RALNFSSDFI PSTTEQLEEP ADEKEAPVEH IRTPPSTPIK
PEGDGYAKEY LLP
//
