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Database: UniProt
Entry: F6QTC2_HORSE
LinkDB: F6QTC2_HORSE
Original site: F6QTC2_HORSE 
ID   F6QTC2_HORSE            Unreviewed;       596 AA.
AC   F6QTC2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   05-JUN-2019, entry version 52.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000010896};
GN   Name=MCAM {ECO:0000313|Ensembl:ENSECAP00000010896};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010896, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000010896, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010896,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000010896}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010896};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   PaxDb; F6QTC2; -.
DR   PRIDE; F6QTC2; -.
DR   Ensembl; ENSECAT00000013706; ENSECAP00000010896; ENSECAG00000013036.
DR   eggNOG; ENOG410IEC2; Eukaryota.
DR   eggNOG; ENOG4110RPG; LUCA.
DR   GeneTree; ENSGT00940000155838; -.
DR   InParanoid; F6QTC2; -.
DR   OMA; NITVHYP; -.
DR   TreeFam; TF330534; -.
DR   Proteomes; UP000002281; Chromosome 7.
DR   Bgee; ENSECAG00000013036; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 5.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 4.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   PROSITE; PS50835; IG_LIKE; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00289593};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS01086444};
KW   Membrane {ECO:0000256|SAAS:SAAS00555457, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Repeat {ECO:0000256|SAAS:SAAS00441186};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00555511,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00555568,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    596       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5018567472.
FT   TRANSMEM    552    575       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      139    242       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      244    332       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      344    424       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      431    510       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   REGION      524    544       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6QTC2}.
FT   COMPBIAS    524    538       Polar. {ECO:0000256|MobiDB-lite:F6QTC2}.
SQ   SEQUENCE   596 AA;  65848 MW;  B09F6B203EA94F82 CRC64;
     MELSRLVCAF LLAACCCCRR AAGVPGEAEQ PEPELVEVEV GGTALLKCGP SHSQGNFGHV
     DWFSVHKEKP TLIFRVHQGL GQSQPGEYQH RLSLQDKGTT LALAHITPHD ERIFLCQGKR
     PQSQEHRIQL RVYKAPEEPS IQVNAVGISV NSQEPEEVAT CVGRNGYPVP QVIWYKNGRP
     LKEEKNRVHI QSSQIVESSG LYTLQSVLKA QLVKEDKDAQ FYCELNYRLP SGNHMKESKE
     VTVPVFYPAE KVWLEVEPVG MLKEGDRVEI RCLADGNPPP HFSISKQNLS TREMEEETTD
     DNGILVLEPA QKEHSGVYEC HGLDLETTTS LQSDQQELLV NYVSDVRVRP AAPESQEGSS
     LTLTCEAESN QAIEFQWLRE KTGKLLQKGP VLQLYNLKRE EGGGYRCVAS VPSVPGLNRT
     QLVNVAVFGS PWMTVKERKV WVKENTVLNL SCEASGHPRP TISWNVDGMA SEQDQDPQSV
     LSILNVLVTP ELLETGAECV ASNSLGKNTT IIFLELDSNR TTGLSTSTVS PHAKANSTST
     EKKLPEPESK GVVIVAVTVC ILVLAVLGAV LYFFYKKGKL PCGRSGKQEM ERNTSI
//
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