ID F6QWC7_HORSE Unreviewed; 1121 AA.
AC F6QWC7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Calcium voltage-gated channel auxiliary subunit alpha2delta 2 {ECO:0000313|Ensembl:ENSECAP00000003220.4};
GN Name=CACNA2D2 {ECO:0000313|VGNC:VGNC:56718};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003220.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000003220.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003220.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000003220.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003220.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000256|ARBA:ARBA00007060}.
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DR AlphaFoldDB; F6QWC7; -.
DR Ensembl; ENSECAT00000004641.4; ENSECAP00000003220.4; ENSECAG00000001156.4.
DR VGNC; VGNC:56718; CACNA2D2.
DR GeneTree; ENSGT00940000156238; -.
DR HOGENOM; CLU_004660_0_0_1; -.
DR TreeFam; TF315824; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000001156; Expressed in retina and 16 other cell types or tissues.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR CDD; cd01463; vWA_VGCC_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-2; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 44..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 294..472
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..38
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 126680 MW; FD6A01DC912748ED CRC64;
MAVPAQTCGA SRPGPARTAL PWPGRSPRPG PGARRPAARP PRPLLLLLPP LLLLPLLAAP
GASAYSFPQQ HTMQHWARRL EQEIDGVMRI FGGVQQLREI YKDNRNLFEV QENEPQKLVE
KVAGDIESLL DRKVQALKKL ADAAENFQKA HRWQDNIKEE DIMYYDAKAD AELDDPESED
VERGSKASNL RLDFVEDSNF KNKVNYSYTA VQIPTDIYKG STVILNELNW TEALENVFIE
NRRQDPTLLW QVFGSATGVT RYYPATPWRA PKKIDLYDVR RRPWYIQGAS SPKDMVIIVD
VSGSVSGLTL KLMKTSVCEM LDTLSDDDYV NVASFNEKAQ PVSCFTHLVQ ANVRNKKVFK
EAVQGMVAKG TTGYKAGFEY AFDQLQNSNI TRANCNKMIM MFTDGGEDRV QDVFEKYNWP
NRTVRVFTFS VGQHNYDVTP LQWMACANKG YYFEIPSIGA IRINTQEYLD VLGRPMVLAG
KEAKQVQWTN VYEDALGLGL VVTGTLPVFN LTQDGPGEKK NQLILGVMGI DVALNDIKRL
TPNYTTTNFR EPVTLDFLDA ELEDENKEEI RRSMIDGNKG HKQIRTLVKS LDERYIDEVM
RNYTWVPIRS TNYSLGLVLP PYSTFYLQAN LSDQILQVKY FEFLLPSSFE SEGHVFIAPR
EYCKDLNASD NNTEFLKNFI ELMEKVTPDS KQCNNFLLHN LILDTGITQQ LVERVWRDQD
LNTYSLLAVF AATDGGITRI FPNKAAEDWT ENPEPFNASF YRRSLDNHGY VFKPPHQDAL
LRPLELENDT VGILVSTAVE LSLGGRTLRP AVVGVKLDLE AWAEKFKVLA SNRTHQDQPQ
KCGPSSHCEM DCEVNNEDLL CILIDDGGFL VLSNQNHQWD QVGRFFSEVD ANLMMALYNN
SFYTRKESYD YQAACAPQPQ GNLGAAPRGV FVPTVADFLN LAWWTSAAAW SLFQQLLYGL
ISHSWFQADP AEAESNPEAR ESSCVMKQTQ YYFGSVNASY NAIIDCGNCS RLFHAQRLTN
TNLLFVVAEK PLCSQCEAGR LLQKETHSDG PEQCELVQRP RYRRGPHICF DYNATEDTSD
CGRGASFPPS LGVLVSLQLL LLLGLPPRPQ PQVYAYASRR L
//
