ID F6QY26_HORSE Unreviewed; 231 AA.
AC F6QY26;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Interleukin 22 receptor subunit alpha 2 {ECO:0000313|Ensembl:ENSECAP00000006850.1};
GN Name=IL22RA2 {ECO:0000313|Ensembl:ENSECAP00000006850.1,
GN ECO:0000313|VGNC:VGNC:19020};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000006850.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000006850.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006850.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000006850.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006850.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_001503623.2; XM_001503573.4.
DR AlphaFoldDB; F6QY26; -.
DR SMR; F6QY26; -.
DR STRING; 9796.ENSECAP00000006850; -.
DR PaxDb; 9796-ENSECAP00000006850; -.
DR Ensembl; ENSECAT00000009062.3; ENSECAP00000006850.1; ENSECAG00000008817.4.
DR GeneID; 100073194; -.
DR KEGG; ecb:100073194; -.
DR CTD; 116379; -.
DR VGNC; VGNC:19020; IL22RA2.
DR GeneTree; ENSGT00940000161124; -.
DR HOGENOM; CLU_081158_1_0_1; -.
DR InParanoid; F6QY26; -.
DR OMA; SMENYYE; -.
DR OrthoDB; 5307423at2759; -.
DR TreeFam; TF332537; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000008817; Expressed in bone marrow and 11 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0042017; F:interleukin-22 binding; IEA:Ensembl.
DR GO; GO:0042018; F:interleukin-22 receptor activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0042509; P:regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR PANTHER; PTHR20859:SF51; INTERLEUKIN-22 RECEPTOR SUBUNIT ALPHA-2; 1.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..231
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003345323"
FT DOMAIN 8..114
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF01108"
FT DOMAIN 126..230
FT /note="Interferon/interleukin receptor"
FT /evidence="ECO:0000259|Pfam:PF09294"
SQ SEQUENCE 231 AA; 26785 MW; 0ADE4414C02B2DDB CRC64;
MMPPHAFLGF LIGLSLTRAA ETQPDHASLK PQRVHFQSRN FHNVLHWRPG RACTGNSSLY
FVQYKMYGQR QWTNKETCWG IQEFFCDLTN ETSAIQEPYY GRVKTASAGI HSGWTMTRRF
IPWWETKIDP PVMNITQVNG SLLVILHAPN LPHRDQKGNS VSMDNYYQLV YRVFIISNSL
EKEQKVYEGA HRVIEVEALA PHAVYCVVAE IYRPELDRRS QRSEERCVTI P
//
