ID F6R031_BOVIN Unreviewed; 668 AA.
AC F6R031;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=3'-phosphoadenosine 5'-phosphosulfate synthase 1 {ECO:0000313|Ensembl:ENSBTAP00000017229.3};
GN Name=PAPSS1 {ECO:0000313|Ensembl:ENSBTAP00000017229.3,
GN ECO:0000313|VGNC:VGNC:53770};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000017229.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000017229.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000017229.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000017229.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000017229.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Sulfur metabolism; sulfate assimilation.
CC {ECO:0000256|ARBA:ARBA00005050}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the sulfate
CC adenylyltransferase family. {ECO:0000256|ARBA:ARBA00009290}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the APS kinase
CC family. {ECO:0000256|ARBA:ARBA00007268}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6R031; -.
DR SMR; F6R031; -.
DR STRING; 9913.ENSBTAP00000017229; -.
DR Ensembl; ENSBTAT00000017229.3; ENSBTAP00000017229.3; ENSBTAG00000012961.3.
DR VEuPathDB; HostDB:ENSBTAG00000012961; -.
DR VGNC; VGNC:53770; PAPSS1.
DR GeneTree; ENSGT00390000009613; -.
DR InParanoid; F6R031; -.
DR TreeFam; TF313143; -.
DR Reactome; R-BTA-174362; Transport and synthesis of PAPS.
DR UniPathway; UPA00097; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000012961; Expressed in floor plate of diencephalon and 106 other cell types or tissues.
DR ExpressionAtlas; F6R031; baseline and differential.
DR GO; GO:0004020; F:adenylylsulfate kinase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004781; F:sulfate adenylyltransferase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0050428; P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; IBA:GO_Central.
DR GO; GO:0000103; P:sulfate assimilation; IBA:GO_Central.
DR CDD; cd02027; APSK; 1.
DR CDD; cd00517; ATPS; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.10.400.10; Sulfate adenylyltransferase; 1.
DR HAMAP; MF_00065; Adenylyl_sulf_kinase; 1.
DR InterPro; IPR002891; APS_kinase.
DR InterPro; IPR025980; ATP-Sase_PUA-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR024951; Sulfurylase_cat_dom.
DR InterPro; IPR002650; Sulphate_adenylyltransferase.
DR NCBIfam; TIGR00455; apsK; 1.
DR NCBIfam; TIGR00339; sopT; 1.
DR PANTHER; PTHR11055; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE; 1.
DR PANTHER; PTHR11055:SF17; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1; 1.
DR Pfam; PF01583; APS_kinase; 1.
DR Pfam; PF01747; ATP-sulfurylase; 1.
DR Pfam; PF14306; PUA_2; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..668
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018639186"
FT DOMAIN 277..429
FT /note="ATP-sulfurylase PUA-like"
FT /evidence="ECO:0000259|Pfam:PF14306"
FT DOMAIN 438..661
FT /note="Sulphate adenylyltransferase catalytic"
FT /evidence="ECO:0000259|Pfam:PF01747"
SQ SEQUENCE 668 AA; 76137 MW; C4BB9F6794FC632F CRC64;
MSFTFAVCVW LVSVQKVNFS HQQLCELKLF SHCALQFVHM GLHLLSGLFT VRWDVEQMCL
CPLQGMQRAT NVTYQAHHVS RNKRGQVVGT RGGFRGCTVW LTGLSGAGKT TVSMALEEYL
VCHGIPCYTL DGDNIRQGLN KNLGFSPEDR EENVRRIAEV AKLFADAGLV CITSFISPYT
QDRNNARRIH EGASLPFFEV FVDAPLHVCE QRDVKGLYKK ARAGEIKGFT GIDSEYEKPE
APELVLKTDS CDVNDCVQQV VELLQERDIV PVDASYEVKE LYVPENKLHL AKTDAETLPA
LKINKVDLQW VQVLAEGWAT PLNGFMRERE YLQCLHFDCL LDGGVINLSV PIVLTATQED
KERLDGCTAF ALMYEGRRVA ILRNPEFFEH RKEERCARQW GTTCKNHPYI KMVMEQGDWL
IGGDLQVLDR IYWNDGLDQY RFTPTELKQK FKDMNADAVF AFQLRNPVHN GHALLMQDTH
RQLLERGYRR PVLLLHPLGG WTKDDDVPLM WRMKQHAAVL EEGVLNPETT VVAIFPSPMM
YAGPTEVQWH CRARMVAGAN FYIVGRDPAG MPHPETGKDL YEPTHGAKVL TMAPGLITLE
IVPFRVAAYN KKKKRMDYYD SEHHEDFEFI SGTRMRKLAR EGQKPPEGFM APKAWDVLME
YYKSLEKA
//
